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Title: Erythrocyte tropism of malarial parasites: the reticulocyte appeal
Authors: Leong, Yew Wai
Russell, Bruce
Malleret, Benoit
Rénia, Laurent
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Leong, Y. W., Russell, B., Malleret, B. & Rénia, L. (2022). Erythrocyte tropism of malarial parasites: the reticulocyte appeal. Frontiers in Microbiology, 13, 1022828-.
Project: NMRC/OFIRG/0065/2018 
Journal: Frontiers in Microbiology 
Abstract: Erythrocytes are formed from the enucleation of erythroblasts in the bone marrow, and as erythrocytes develop from immature reticulocytes into mature normocytes, they undergo extensive cellular changes through their passage in the blood. During the blood stage of the malarial parasite life cycle, the parasite sense and invade susceptible erythrocytes. However, different parasite species display varying erythrocyte tropisms (i.e., preference for either reticulocytes or normocytes). In this review, we explore the erythrocyte tropism of malarial parasites, especially their predilection to invade reticulocytes, as shown from recent studies. We also discuss possible mechanisms mediating erythrocyte tropism and the implications of specific tropisms to disease pathophysiology. Understanding these allows better insight into the role of reticulocytes in malaria and provides opportunities for targeted interventions.
ISSN: 1664-302X
DOI: 10.3389/fmicb.2022.1022828
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: A*STAR Infectious Diseases Labs
Rights: © 2022 Leong, Russell, Malleret and Rénia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
SBS Journal Articles

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