Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164555
Title: Aging is associated with prolonged hospitalisation stay in pyogenic liver abscess - A 1:1 propensity score matched study in elderly versus non-elderly patients
Authors: Chan, Kai Siang
Junnarkar, Sameer P.
Low, Jee Keem
Huey, Terence Cheong Wei
Shelat, Vishal G.
Keywords: Science::Medicine
Issue Date: 2022
Source: Chan, K. S., Junnarkar, S. P., Low, J. K., Huey, T. C. W. & Shelat, V. G. (2022). Aging is associated with prolonged hospitalisation stay in pyogenic liver abscess - A 1:1 propensity score matched study in elderly versus non-elderly patients. The Malaysian Journal of Medical Sciences, 29(5), 59-73. https://dx.doi.org/10.21315/mjms2022.29.5.7
Journal: The Malaysian Journal of Medical Sciences
Abstract: Background: Mortality of pyogenic liver abscess (PLA) is high ranging 10%–40%. Old age predicts outcomes in many diseases but there is paucity of data on PLA outcomes. We aim to compare the morbidity and mortality between elderly and non-elderly in PLA. Methods: This is a retrospective study from 2007–2011 comparing elderly (≥ 65 years old) and non-elderly (< 65 years old) with PLA. A 1:1 propensity score matching (PSM) was performed. Baseline clinical profile and outcomes were compared. Results: There were 213 patients (elderly patients = 90 [42.3%], non-elderly patients = 123 [57.7%]). Overall median age is 62 (interquartile range [IQR] = 53–74) years old. PSM resulted in 102 patients (51 per arm). Length of hospitalisation stay (LOS) was significantly longer in elderly patients in both unmatched (16 [IQR = 10–24.5] versus 11 [IQR = 8–19] days; P < 0.001) and matched cohorts (17 [IQR = 13–27] versus 11 [IQR = 7–19] days; P = 0.001). In-hospital mortality was significantly higher in elderly patients in the unmatched cohort (elderly patients = 21.1%, nonelderly patients = 7.3%; P = 0.003) but was insignificant following PSM (elderly patients = 15.7%, non-elderly patients = 9.8%; P = 0.219). Duration of antibiotic therapy and need for percutaneous drainage (PD) were comparable before and after PSM. Conclusion: Age ≥ 65 years old is associated with longer LOS. In-hospital mortality though higher in elderly patients, was not statistically significant.
URI: https://hdl.handle.net/10356/164555
ISSN: 1394-195X
DOI: 10.21315/mjms2022.29.5.7
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Tan Tock Seng Hospital
Rights: © Penerbit Universiti Sains Malaysia, 2022. This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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