Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164559
Title: Telomeric chromatin structure
Authors: Soman, Aghil
Korolev, Nikolay
Nordenskiöld, Lars
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Soman, A., Korolev, N. & Nordenskiöld, L. (2022). Telomeric chromatin structure. Current Opinion in Structural Biology, 77, 102492-. https://dx.doi.org/10.1016/j.sbi.2022.102492
Project: MOE2018-T2-1-112
Journal: Current opinion in structural biology
Abstract: Eukaryotic DNA is packaged into nucleosomes, which further condenses into chromosomes. The telomeres, which form the protective end-capping of chromosomes, play a pivotal role in ageing and cancer. Recently, significant advances have been made in understanding the nucleosomal and telomeric chromatin structure at the molecular level. In addition, recent studies shed light on the nucleosomal organisation at telomeres revealing its ultrastructural organisation, the atomic structure at the nucleosome level, its dynamic properties, and higher-order packaging of telomeric chromatin. Considerable advances have furthermore been made in understanding the structure, function and organisation of shelterin, telomerase and CST complexes. Here we discuss these recent advances in the organisation of telomeric nucleosomes and chromatin and highlight progress in the structural understanding of shelterin, telomerase and CST complexes.
URI: https://hdl.handle.net/10356/164559
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2022.102492
Schools: School of Biological Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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