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Title: Inflammatory biomarkers and motoric cognitive risk syndrome: multicohort survey
Authors: Groeger, Justina L.
Ayers, Emmeline
Barzilai, Nir
Beauchet, Olivier
Callisaya, Michele
Torossian, Maral R.
Derby, Carol
Doi, Takehiko
Lipton, Richard B.
Milman, Sofiya
Nakakubo, Sho
Shimada, Hiroyuki
Srikanth, Velandai
Wang, Cuiling
Verghese, Joe
Keywords: Science::Medicine
Issue Date: 2022
Source: Groeger, J. L., Ayers, E., Barzilai, N., Beauchet, O., Callisaya, M., Torossian, M. R., Derby, C., Doi, T., Lipton, R. B., Milman, S., Nakakubo, S., Shimada, H., Srikanth, V., Wang, C. & Verghese, J. (2022). Inflammatory biomarkers and motoric cognitive risk syndrome: multicohort survey. Cerebral Circulation - Cognition and Behavior, 3, 100151-.
Journal: Cerebral Circulation - Cognition and Behavior 
Abstract: Background: Inflammation may play a role in Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome comprised of slow gait and cognitive complaints. Our objective was to examine associations of inflammatory biomarkers with MCR. Methods: We examined association of interleukin-6 (IL-6) and C-reactive protein (CRP) with prevalent MCR using logistic regression in 3,101 older adults (52% female) from five cohorts (National Center for Geriatrics & Gerontology Study of Geriatric Syndromes [NCGG-SGS], Central Control of Mobility in Aging [CCMA], Tasmanian Study of Cognition and Gait [TASCOG], LonGenity, and Einstein Aging Study [EAS]). Associations were reported as odds ratios adjusted for sex, age, education, depressive symptoms, body mass index, and vascular diseases (aOR) with 95% confidence intervals (CI). Meta-analysis and analyses stratified by vascular disease were also done. Results: Although associations between higher (worse) CRP and IL-6 tertiles and MCR were only seen in three out of the five cohorts (EAS, TASCOG, and LonGenity), when a pooled meta-analysis was performed, a robust association was demonstrated. In meta-analysis, highest tertiles of IL-6 (aOR 1.57, 95%CI 1.01- 2.44) and CRP (aOR 1.65, 95%CI 1.09–2.48) was associated with MCR versus lowest tertiles in the pooled sample. Higher CRP was associated with MCR among those with vascular disease in TASCOG and LonGenity cohorts, and among those without vascular disease in EAS. Conclusions: IL-6 and CRP levels are associated with MCR in older adults, and this association varies by presence of vascular disease.
ISSN: 2666-2450
DOI: 10.1016/j.cccb.2022.100151
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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