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Title: Chemical basis of combination therapy to combat antibiotic resistance
Authors: Si, Zhangyong
Pethe, Kevin
Chan-Park, Mary B.
Keywords: Science::Chemistry::Biochemistry
Issue Date: 2023
Source: Si, Z., Pethe, K. & Chan-Park, M. B. (2023). Chemical basis of combination therapy to combat antibiotic resistance. JACS Au.
Project: MOE2018-T3-1-003 
Journal: JACS Au 
Abstract: The antimicrobial resistance crisis is a global health issue requiring discovery and development of novel therapeutics. However, conventional screening of natural products or synthetic chemical libraries is uncertain. Combination therapy using approved antibiotics with inhibitors targeting innate resistance mechanisms provides an alternative strategy to develop potent therapeutics. This review discusses the chemical structures of effective β-lactamase inhibitors, outer membrane permeabilizers, and efflux pump inhibitors that act as adjuvant molecules of classical antibiotics. Rational design of the chemical structures of adjuvants will provide methods to impart or restore efficacy to classical antibiotics for inherently antibiotic-resistant bacteria. As many bacteria have multiple resistance pathways, adjuvant molecules simultaneously targeting multiple pathways are promising approaches to combat multi-drug-resistant bacterial infections.
ISSN: 2691-3704
DOI: 10.1021/jacsau.2c00532
Schools: School of Chemical and Biomedical Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) 
Rights: © 2023 The Authors. All rights reserved. This paper was published by American Chemical Society in JACS Au and is made available with permission of The Authors.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles
LKCMedicine Journal Articles
SCELSE Journal Articles

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