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Title: A review of membrane fouling by proteins in ultrafiltration and microfiltration
Authors: Tanudjaja, Henry Jonathan
Anantharaman, Aditya
Ng, Angie Qi Qi
Ma, Yunqiao
Tanis-Kanbur, Melike Begüm
Zydney, Andrew L.
Chew, Jia Wei
Keywords: Engineering::Civil engineering
Issue Date: 2022
Source: Tanudjaja, H. J., Anantharaman, A., Ng, A. Q. Q., Ma, Y., Tanis-Kanbur, M. B., Zydney, A. L. & Chew, J. W. (2022). A review of membrane fouling by proteins in ultrafiltration and microfiltration. Journal of Water Process Engineering, 50, 103294-.
Project: A20B3a0070
Journal: Journal of Water Process Engineering
Abstract: Fouling of ultrafiltration (UF) and microfiltration (MF) membranes by proteins is a major challenge in the bioprocessing and dairy industries, as well as in surface and wastewater treatment applications. This review attempts at presenting a comprehensive state-of-the-art understanding on protein fouling of membranes. Effects of operating conditions, along with properties of proteins and membranes, are discussed. Various tools and techniques used to characterize and monitor fouling are described. Different mitigation techniques and cleaning methods used are also presented. Two main factors have been identified as playing important roles in governing protein fouling, namely, ratio of protein size to membrane pore size and interfacial interactions (i.e., protein-protein and protein-membrane). Some directions for future research are suggested: (1) explore a wider range of proteins and their mixtures with respect to their fouling tendencies; and (2) create a comprehensive dataset that can be used to develop machine-learning models to enhance both predictive capabilities and mechanistic understanding.
ISSN: 2214-7144
DOI: 10.1016/j.jwpe.2022.103294
Schools: School of Chemical and Biomedical Engineering 
Interdisciplinary Graduate School (IGS) 
Research Centres: Singapore Membrane Technology Centre 
Nanyang Environment and Water Research Institute 
Rights: © 2022 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:IGS Journal Articles
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