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dc.contributor.authorEllis, Elizabethen_US
dc.contributor.authorDjordjevic, Ivanen_US
dc.contributor.authorMuhammad Naziruddin Bin Mohd Alien_US
dc.contributor.authorSteele, Terry W. J.en_US
dc.identifier.citationEllis, E., Djordjevic, I., Muhammad Naziruddin Bin Mohd Ali & Steele, T. W. J. (2023). Carbene-based bioadhesive blended with amine, thiol, and acrylate liquid additives. ACS Applied Polymer Materials.
dc.description.abstractLight activated carbenes provide a unique method of non-specific covalent bond formation needed in bioadhesives and rapid gelation. The highly reactive carbenes formed upon UV irradiation allow for binding to a wide range of natural and synthetic substrates in addition to cohesive bonds. However, little is known about how these crosslinkers would behave in the presence of additives, which are important for tuning material properties. This work investigates carbene based bioadhesives in the presence of various liquid additives containing reactive functional groups of hydroxyl, thiol, amine, or acrylate. Steady shear viscosity, dynamic mechanical properties, microstructure, and reactive functional groups are evaluated by photorheometry, scanning electron microscopy (SEM), and FTIR spectroscopy. The triol hydroxy additive maintains the storage modulus despite dilution of the diazirine crosslinker. The thiol additive reduces apparent viscosity whilst maintaining material properties. Polyamine accelerates ester hydrolysis and increases hydrophilicity. For the first time diacrylate polymerization is demonstrated by photoactivated diazirine, the carbene precursor. The diacrylate additive displays synergistic enhancement of dynamic modulus within the binary composite, reaching 977 kPa compared to 82 kPa of neat carbene based bioadhesive. The polymerisation of acrylates initiated by diazirine photolysis opens possibilities for acrylate initiation and hybrid composite biomaterials.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.relationMOE-T1-RG17/18 (S)en_US
dc.relation.ispartofACS Applied Polymer Materialsen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Polymer Materials, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org10.1021/acsapm..en_US
dc.subjectScience::Chemistry::Organic chemistry::Polymersen_US
dc.titleCarbene-based bioadhesive blended with amine, thiol, and acrylate liquid additivesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionSubmitted/Accepted versionen_US
dc.subject.keywordsBinary Polymer Compositeen_US
dc.subject.keywordsUV Activationen_US
dc.description.acknowledgementT.W.J.S. and I.D. are co-inventors of patent application: Hygroscopic, Crosslinking Coatings and Bioadhesives; PCT/SG2018/050452. Authors declare no competing interests. The project was supported by A*Star IAF PP Grant (H19/01/a0/0II9): CathoGlu Bioadhesives-preventing catheter extravasation and skin infections; Ministry of Education Tier 1 Grant RG17/18 (S): Novel light activated, diazo protecting groups; Ministry of Education Tier 1 Grant RT07/20: Fiber-optic orthopaedic implants for bone-implant adhesion; Ministry of Education Tier 2 Grant (MOE2018‐T2‐2‐114): CaproGlu, Double sided wet-tissue adhesives; NTUitive POC (Gap) Fund NGF/2018/05: Aesthetic Applications of CaproGlu Bioadhesives. Figures created with
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