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Title: Carbene-based bioadhesive blended with amine, thiol, and acrylate liquid additives
Authors: Ellis, Elizabeth
Djordjevic, Ivan
Muhammad Naziruddin Bin Mohd Ali
Steele, Terry W. J.
Keywords: Engineering::Materials::Biomaterials
Science::Chemistry::Organic chemistry::Polymers
Issue Date: 2023
Source: Ellis, E., Djordjevic, I., Muhammad Naziruddin Bin Mohd Ali & Steele, T. W. J. (2023). Carbene-based bioadhesive blended with amine, thiol, and acrylate liquid additives. ACS Applied Polymer Materials.
Project: H19/01/a0/0II9) 
MOE-T1-RG17/18 (S) 
Journal: ACS Applied Polymer Materials 
Abstract: Light activated carbenes provide a unique method of non-specific covalent bond formation needed in bioadhesives and rapid gelation. The highly reactive carbenes formed upon UV irradiation allow for binding to a wide range of natural and synthetic substrates in addition to cohesive bonds. However, little is known about how these crosslinkers would behave in the presence of additives, which are important for tuning material properties. This work investigates carbene based bioadhesives in the presence of various liquid additives containing reactive functional groups of hydroxyl, thiol, amine, or acrylate. Steady shear viscosity, dynamic mechanical properties, microstructure, and reactive functional groups are evaluated by photorheometry, scanning electron microscopy (SEM), and FTIR spectroscopy. The triol hydroxy additive maintains the storage modulus despite dilution of the diazirine crosslinker. The thiol additive reduces apparent viscosity whilst maintaining material properties. Polyamine accelerates ester hydrolysis and increases hydrophilicity. For the first time diacrylate polymerization is demonstrated by photoactivated diazirine, the carbene precursor. The diacrylate additive displays synergistic enhancement of dynamic modulus within the binary composite, reaching 977 kPa compared to 82 kPa of neat carbene based bioadhesive. The polymerisation of acrylates initiated by diazirine photolysis opens possibilities for acrylate initiation and hybrid composite biomaterials.
ISSN: 2637-6105
DOI: 10.1021/acsapm.2c01658
Schools: School of Materials Science and Engineering 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Polymer Materials, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org10.1021/acsapm..
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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