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Title: Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes
Authors: Das, Poulomi
Phan, Anh Tuân
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Das, P. & Phan, A. T. (2022). Tetrad-binding ligands do not bind specifically to left-handed G-quadruplexes. Chemical Communications, 58(80), 11264-11267.
Project: MOE2015-T2-1- 092
Journal: Chemical Communications
Abstract: G-quadruplexes (G4s) are attractive anticancer targets. While right-handed G4s have been extensively investigated with many specific ligands reported, left-handed G4s formed by natural DNA have been recently discovered. Here we show that ligands specific for right-handed G4s, such as Phen-DC3 and RHAU peptide, do not bind specifically to left-handed G4s. In right-handed G4s, these ligands can displace capping overhangs and/or loops to stack on the exposed terminal tetrads. In contrast, the presence of tight T-capping in left-handed G4s hinders access to the tetrads.
ISSN: 1359-7345
DOI: 10.1039/d2cc03374g
Schools: School of Physical and Mathematical Sciences 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2022 The Royal Society of Chemistry. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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