Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164755
Title: Direct reaction of nitroarenes and thiols via photodriven oxygen atom transfer for access to sulfonamides
Authors: Bao, Zhaowei
Zou, Juan
Mou, Chengli
Jin, Zhichao
Ren, Shi-Chao
Chi, Robin Yonggui
Keywords: Science::Chemistry
Issue Date: 2022
Source: Bao, Z., Zou, J., Mou, C., Jin, Z., Ren, S. & Chi, R. Y. (2022). Direct reaction of nitroarenes and thiols via photodriven oxygen atom transfer for access to sulfonamides. Organic Letters, 24(48), 8907-8913. https://dx.doi.org/10.1021/acs.orglett.2c03770
Project: NRF-NRFI2016-06 
NRF-CRP22-2019-0002 
RG7/20 
RG5/19 
MOE2019-T2-2-117 
MOE2018-T3-1-003 
Journal: Organic Letters 
Abstract: Sulfonamide is a common motif in medicines and agrochemicals. Typically, this class of functional groups is prepared by reacting amines with sulfonyl chlorides that are presynthesized from nitro compounds and thiols, respectively. Here, we report a novel strategy that directly couples nitro compounds and thiols to form sulfonamides atom- and redox-economically. Mechanistic studies suggest our reaction proceeds via direct photoexcitation of nitroarenes that eventually transfers the oxygen atoms from the nitro group to the thiol unit.
URI: https://hdl.handle.net/10356/164755
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.2c03770
Schools: School of Physical and Mathematical Sciences 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org//10.1021/acs.orglett.2c03770.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles
SPMS Journal Articles

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