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Title: Evaluation of the anti-inflammatory and anti-oxidative effects of therapeutic human lactoferrin fragments
Authors: Pan, Yu
Liu, Zhao
Wang, Yijie
Zhang, Linshen
Chua, Niying
Dai, Lei
Chen, Jun
Ho, Chun Loong
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Pan, Y., Liu, Z., Wang, Y., Zhang, L., Chua, N., Dai, L., Chen, J. & Ho, C. L. (2021). Evaluation of the anti-inflammatory and anti-oxidative effects of therapeutic human lactoferrin fragments. Frontiers in Bioengineering and Biotechnology, 9, 779018-.
Journal: Frontiers in Bioengineering and Biotechnology
Abstract: Chronic inflammation is considered a pressing health issue that needs resolving. Inflammatory disease such as inflammatory bowel disease requires a long-term medical regimen to prevent disease progression. Conventionally, lactoferrin is used to treat mild gastrointestinal tract and skin inflammation. Protease-digested lactoferrin fragments often exhibit improved therapeutic properties compared to full-length lactoferrin (flHLF). However, there are no studies on the use of protease-digested lactoferrin fragments to treat inflammation. Herein, we assess the anti-inflammatory properties of engineered recombinant lactoferrin fragments (rtHLF4, rteHLF1, and rpHLF2) on non-malignant colonic fibroblast cells and colorectal cancer cells. We found that rtHLF4 is 10 times more effective to prevent inflammation compared to flHLF. These results were investigated by looking into the reactive oxygen species (ROS) production, angiogenesis activity, and cellular proliferation of the treated cells. We have demonstrated in this study the anti-inflammatory properties of the flHLF and the various lactoferrin fragments. These results complement the anti-cancer properties of these proteins that were demonstrated in an earlier study.
ISSN: 2296-4185
DOI: 10.3389/fbioe.2021.779018
Schools: School of Biological Sciences 
Rights: © 2021 Pan, Liu, Wang, Zhang, Chua, Dai, Chen and Ho. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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