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Title: Experimental models to study the pathogenesis of malaria-associated acute respiratory distress syndrome
Authors: Nguee, Samantha Yee Teng
Júnior, José Wandilson Barboza Duarte
Epiphanio, Sabrina
Rénia, Laurent
Claser, Carla
Keywords: Science::Medicine
Issue Date: 2022
Source: Nguee, S. Y. T., Júnior, J. W. B. D., Epiphanio, S., Rénia, L. & Claser, C. (2022). Experimental models to study the pathogenesis of malaria-associated acute respiratory distress syndrome. Frontiers in Cellular and Infection Microbiology, 12, 899581-.
Journal: Frontiers in Cellular and Infection Microbiology 
Abstract: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is increasingly gaining recognition as a severe malaria complication because of poor prognostic outcomes, high lethality rate, and limited therapeutic interventions. Unfortunately, invasive clinical studies are challenging to conduct and yields insufficient mechanistic insights. These limitations have led to the development of suitable MA-ARDS experimental mouse models. In patients and mice, MA-ARDS is characterized by edematous lung, along with marked infiltration of inflammatory cells and damage of the alveolar-capillary barriers. Although, the pathogenic pathways have yet to be fully understood, the use of different experimental mouse models is fundamental in the identification of mediators of pulmonary vascular damage. In this review, we discuss the current knowledge on endothelial activation, leukocyte recruitment, leukocyte induced-endothelial dysfunction, and other important findings, to better understand the pathogenesis pathways leading to endothelial pulmonary barrier lesions and increased vascular permeability. We also discuss how the advances in imaging techniques can contribute to a better understanding of the lung lesions induced during MA-ARDS, and how it could aid to monitor MA-ARDS severity.
ISSN: 2235-2988
DOI: 10.3389/fcimb.2022.899581
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: A*STAR Infectious Diseases Labs
Rights: © 2022 Nguee, Junior, Epiphanio, Re ́ nia and Claser. This is an open-access ́ article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
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