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Title: Feedback inhibition underlies new computational functions of cerebellar interneurons
Authors: Halverson, Hunter E.
Kim, Jinsook
Khilkevich, Andrei
Mauk, Michael D.
Augustine, George James
Keywords: Science::Medicine
Issue Date: 2022
Source: Halverson, H. E., Kim, J., Khilkevich, A., Mauk, M. D. & Augustine, G. J. (2022). Feedback inhibition underlies new computational functions of cerebellar interneurons. ELife, 11, e77603-.
Project: MOE2017-T3-1-002 
Journal: eLife 
Abstract: The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling. Purkinje cells inhibit a subset of MLIs in the inner third of the molecular layer. This inhibition is non-reciprocal, short-range (less than 200 μm) and is based on convergence of one to two Purkinje cells onto MLIs. During learning-related eyelid movements in vivo, the activity of a subset of MLIs progressively increases as Purkinje cell activity decreases, with Purkinje cells usually leading the MLIs. Computer simulations indicate that these relationships are best explained by the feedback circuit from Purkinje cells to MLIs and that this feedback circuit plays a central role in making cerebellar learning efficient.
ISSN: 2050-084X
DOI: 10.7554/eLife.77603
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Institute of Molecular and Cell Biology, Singapore
Rights: © Halverson, Kim et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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