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Title: Design and self-assembly of guanidinium-functionalized polycarbonates for increased selectivity towards pathogenic bacteria
Authors: Tan, Jason
Keywords: Science::Chemistry
Issue Date: 2023
Publisher: Nanyang Technological University
Source: Tan, J. (2023). Design and self-assembly of guanidinium-functionalized polycarbonates for increased selectivity towards pathogenic bacteria. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Guanidinium-functionalized amphiphilic polycarbonates have recently been proven to be effective in treating infections caused by multidrug resistant bacteria. These positively charged polymers are able to electrostatically interact with the negatively charged microbial membrane, before translocating across to kill the microbe by targeting intracellular proteins and genetic materials. The design of these polymers has been tricky as it is imperative to find the right amphiphilic balance. It is common to increase their hydrophobicity for a more efficient antimicrobial activity. However, at elevated levels of hydrophobicity, they also indiscriminately disrupt healthy mammalian cell membrane due to enhanced membrane affinity. Moreover, due to their cationic nature, they often interact with the anionic salic acid, found on the surface of red blood cells, resulting in hemagglutination. This has hampered their in vivo application. In this thesis, we address these issues by looking at strategies to improve the selectivity and biocompatibility of these polymers.
DOI: 10.32657/10356/164855
Schools: School of Chemistry, Chemical Engineering and Biotechnology
Organisations: Institute of Bioengineering and Bioimaging (IBB), A*STAR
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20250220
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Theses

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