Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/164864
Title: A multi-regression approach to improve optical coherence tomography diagnostic accuracy in multiple sclerosis patients without previous optic neuritis
Authors: Chua, Jacqueline
Bostan, Mihai
Li, Chi
Sim, Yin Ci
Bujor, Inna
Wong, Damon
Tan, Bingyao
Yao, Xinwen
Schwarzhans, Florian
Garhöfer, Gerhard
Fischer, Georg
Vass, Clemens
Tiu, Cristina
Pirvulescu, Ruxandra
Popa-Cherecheanu, Alina
Schmetterer, Leopold
Keywords: Engineering::Bioengineering
Issue Date: 2022
Source: Chua, J., Bostan, M., Li, C., Sim, Y. C., Bujor, I., Wong, D., Tan, B., Yao, X., Schwarzhans, F., Garhöfer, G., Fischer, G., Vass, C., Tiu, C., Pirvulescu, R., Popa-Cherecheanu, A. & Schmetterer, L. (2022). A multi-regression approach to improve optical coherence tomography diagnostic accuracy in multiple sclerosis patients without previous optic neuritis. NeuroImage: Clinical, 34, 103010-. https://dx.doi.org/10.1016/j.nicl.2022.103010
Project: CG/C010A/2017_SERI 
OFIRG/0048/2017 
OFLCG/004c/2018 
TA/MOH-000249-00/2018 
MOH-OFIRG20nov-0014 
NMRC/CG2/004b/2022-SERI 
NRF2019-THE002-0006 
NRF-CRP24-2020-0001 
A20H4b0141 
Duke-NUS-KP(Coll)/2018/0009A 
LF1019-1 
Journal: NeuroImage: Clinical 
Abstract: Background: Optical coherence tomography (OCT) is a retinal imaging system that may improve the diagnosis of multiple sclerosis (MS) persons, but the evidence is currently equivocal. To assess whether compensating the peripapillary retinal nerve fiber layer (pRNFL) thickness for ocular anatomical features as well as the combination with macular layers can improve the capability of OCT in differentiating non-optic neuritis eyes of relapsing-remitting MS patients from healthy controls. Methods: 74 MS participants (n = 129 eyes) and 84 age- and sex-matched healthy controls (n = 149 eyes) were enrolled. Macular ganglion cell complex (mGCC) thickness was extracted and pRNFL measurement was compensated for ocular anatomical factors. Thickness measurements and their corresponding areas under the receiver operating characteristic curves (AUCs) were compared between groups. Results: Participants with MS showed significantly thinner mGCC, measured and compensated pRNFL (p ≤ 0.026). Compensated pRNFL achieved better performance than measured pRNFL for MS differentiation (AUC, 0.75 vs 0.80; p = 0.020). Combining macular and compensated pRNFL parameters provided the best discrimination of MS (AUC = 0.85 vs 0.75; p < 0.001), translating to an average improvement in sensitivity of 24 percent for differentiation of MS individuals. Conclusion: The capability of OCT in MS differentiation is made more robust by accounting OCT scans for individual anatomical differences and incorporating information from both optic disc and macular regions, representing markers of axonal damage and neuronal injury, respectively.
URI: https://hdl.handle.net/10356/164864
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2022.103010
Schools: School of Chemical and Biomedical Engineering 
Organisations: Singapore Eye Research Institute 
SERI-NTU Advanced Ocular Engineering (STANCE), Singapore 
Duke-NUS Medical School 
Rights: © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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