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dc.contributor.authorHwang, Jangsunen_US
dc.contributor.authorSeo, Youngminen_US
dc.contributor.authorJeong, Daunen_US
dc.contributor.authorNing, Xiaoyuen_US
dc.contributor.authorWiraja, Christianen_US
dc.contributor.authorYang, Lixiaen_US
dc.contributor.authorTan, Chew Tengen_US
dc.contributor.authorLee, Jinhyucken_US
dc.contributor.authorKim, Yesolen_US
dc.contributor.authorKim, Ji Wonen_US
dc.contributor.authorKim, Dai Hyunen_US
dc.contributor.authorChoi, Jonghoonen_US
dc.contributor.authorLim, Chin Yanen_US
dc.contributor.authorPu, Kanyien_US
dc.contributor.authorJang, Woo Youngen_US
dc.contributor.authorXu, Chenjieen_US
dc.identifier.citationHwang, J., Seo, Y., Jeong, D., Ning, X., Wiraja, C., Yang, L., Tan, C. T., Lee, J., Kim, Y., Kim, J. W., Kim, D. H., Choi, J., Lim, C. Y., Pu, K., Jang, W. Y. & Xu, C. (2022). Monitoring wound healing with topically applied optical NanoFlare mRNA nanosensors. Advanced Science, 9(18), e2104835-.
dc.description.abstractAn effective wound management strategy needs accurate assessment of wound status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However, existing methods for quantifying these biomarkers such as immunohistochemistry and quantitative polymerase chain reaction are usually laborious, resource-intensive, and disruptive. This article reports the development and utilization of mRNA nanosensors (i.e., NanoFlare) that are topically applied on cutaneous wounds to reveal the healing status through targeted and semi-quantitative examination of the mRNA biomarkers in skin cells. In 2D and 3D in vitro models, the efficacy and efficiency of these nanosensors are demonstrated in revealing the dynamic changes of mRNA biomarkers for different stages of wound development. In mouse models, this platform permits the tracking and identification of wound healing stages and a normal and diabetic wound healing process by wound healing index in real time.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.relation.ispartofAdvanced Scienceen_US
dc.rights© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.titleMonitoring wound healing with topically applied optical NanoFlare mRNA nanosensorsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.researchNTU Institute for Health Technologiesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsDiabetic Wounden_US
dc.subject.keywordsmRNA Nanosensorsen_US
dc.description.acknowledgementThis project is supported by Singapore Agency for Science, Technology and Research (A*STAR) Science and Engineering Research Council Additive Manufacturing for Biological Materials (AMBM) program (A18A8b0059).C.X. acknowledges the funding support from City University of Hong Kong(9610472), General Research Fund (GRF) from University Grant Commit-tee of Hong Kong (UGC) Research Grant Council (RGC) (9042951 and9043133), NSFC/RGC Joint Research Scheme (N_CityU118/20), and the Germany/Hong Kong Joint Research Scheme sponsored by the RGC of Hong Kong and the Germany Academic Exchange Service of Germany(CityU101/21). This work is also partially supported by the Korea Medical Device Development Fund from the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety)(KMDF_PR_20200901_0039).en_US
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