Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/165515
Title: Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy
Authors: Feng, Lili
Zhao, Ruoxi
Yang, Lu
Liu, Bin
Dong, Shuming
Qian, Cheng
Liu, Jiawei
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2023
Source: Feng, L., Zhao, R., Yang, L., Liu, B., Dong, S., Qian, C., Liu, J. & Zhao, Y. (2023). Tumor-specific NIR-activatable nanoreactor for self-enhanced multimodal imaging and cancer phototherapy. ACS Nano, 17(2), 1622-1637. https://dx.doi.org/10.1021/acsnano.2c11470
Project: A20E5c0081 
NRFNRFI2018-03 
Journal: ACS Nano 
Abstract: Responsive nanosystems for tumor treatment with high specificity and sensitivity have aroused great attention. Herein, we develop a tumor microenvironment responsive and near-infrared (NIR)-activatable theranostic nanoreactor for imaging-guided anticancer therapy. The nanoreactor (SnO2–x@AGP) is comprised of poly(vinylpyrrolidine) encapsulated hollow mesoporous black SnO2–x nanoparticles coloaded with glucose oxidase (GOx) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). The constructed nanoreactor can be specifically activated through endogenous H2O2 by an NIR-mediated “bursting-like” process to enhance its imaging and therapeutic functions. Black SnO2–x with abundant oxygen vacancies expedites effective separation of electron–hole pairs from energy-band structure and endows them with strong hyperthermia effect upon NIR laser irradiation. The generating toxic H2O2 with the assistance of GOx provides SnO2–x@AGP with the capacity of oxidative stress therapy. Ascended H2O2 can activate ABTS into ABTS•+. ABTS•+ not only possesses significant NIR absorption properties, but also disrupts intracellular glutathione to generate excessive reactive oxygen species for improved phototherapy, leading to more effective treatment together with oxidative stress therapy. Thus, SnO2–x@AGP with NIR-mediated and H2O2-activated performance presents tumor inhibition efficacy with minimized damage to normal tissues. These outstanding characteristics of SnO2–x@AGP bring an insight into the development of activatable nanoreactors for smart, precise, and non-invasive cancer theranostics.
URI: https://hdl.handle.net/10356/165515
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c11470
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2023 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.2c11470.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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