Please use this identifier to cite or link to this item:
Title: Highly effective generation of singlet oxygen by an imidazole-linked robust photosensitizing covalent organic framework
Authors: Luan, Tian-Xiang
Du, Lehan
Wang, Jia-Rui
Li, Keyu
Zhang, Quan
Li, Pei-Zhou
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Luan, T., Du, L., Wang, J., Li, K., Zhang, Q., Li, P. & Zhao, Y. (2022). Highly effective generation of singlet oxygen by an imidazole-linked robust photosensitizing covalent organic framework. ACS Nano, 16(12), 21565-21575.
Project: RG3/21 
Journal: ACS Nano 
Abstract: Developing effective photosensitizers to initiate the generation of singlet oxygen (1O2) is of great significance in both chemistry and physiology. Herein, linking the photoactive porphyrin moieties by in situ-formed robust imidazole groups, a covalent organic framework (COF), PyPor-COF, was successfully designed and synthesized. Detailed characterizations reveal that it not only possesses high crystallinity, permanent porosity, and robust stability but also shows a semiconductive photoresponse activity. As demonstrated by electron paramagnetic resonance experiments, the COF can initiate the generation of 1O2 efficiently under visible-light irradiation, the efficiency of which is higher than that of the pristine porphyrin-based reactant and even higher than some commonly used commercially available photosensitizing agents. Anticancer experiments prove that it can efficiently trigger the production of 1O2 in a physiological environment. This work demonstrates that the imidazole-linked porphyrin-incorporated COF is a highly promising photosensitizer that can even be applied in photodynamic therapy.
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c10423
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

Files in This Item:
File Description SizeFormat 
Manuscript.pdf2.28 MBAdobe PDFThumbnail

Citations 20

Updated on Feb 24, 2024

Web of ScienceTM
Citations 20

Updated on Oct 30, 2023

Page view(s)

Updated on Mar 3, 2024


Updated on Mar 3, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.