Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/165544
Title: Highly effective generation of singlet oxygen by an imidazole-linked robust photosensitizing covalent organic framework
Authors: Luan, Tian-Xiang
Du, Lehan
Wang, Jia-Rui
Li, Keyu
Zhang, Quan
Li, Pei-Zhou
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Luan, T., Du, L., Wang, J., Li, K., Zhang, Q., Li, P. & Zhao, Y. (2022). Highly effective generation of singlet oxygen by an imidazole-linked robust photosensitizing covalent organic framework. ACS Nano, 16(12), 21565-21575. https://dx.doi.org/10.1021/acsnano.2c10423
Project: RG3/21 
MOET2EP10120-0003 
Journal: ACS Nano 
Abstract: Developing effective photosensitizers to initiate the generation of singlet oxygen (1O2) is of great significance in both chemistry and physiology. Herein, linking the photoactive porphyrin moieties by in situ-formed robust imidazole groups, a covalent organic framework (COF), PyPor-COF, was successfully designed and synthesized. Detailed characterizations reveal that it not only possesses high crystallinity, permanent porosity, and robust stability but also shows a semiconductive photoresponse activity. As demonstrated by electron paramagnetic resonance experiments, the COF can initiate the generation of 1O2 efficiently under visible-light irradiation, the efficiency of which is higher than that of the pristine porphyrin-based reactant and even higher than some commonly used commercially available photosensitizing agents. Anticancer experiments prove that it can efficiently trigger the production of 1O2 in a physiological environment. This work demonstrates that the imidazole-linked porphyrin-incorporated COF is a highly promising photosensitizer that can even be applied in photodynamic therapy.
URI: https://hdl.handle.net/10356/165544
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c10423
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.2c10423.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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