Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/165552
Title: Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy
Authors: Ding, Chendi
Chen, Chunbo
Zeng, Xiaowei
Chen, Hongzhong
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Ding, C., Chen, C., Zeng, X., Chen, H. & Zhao, Y. (2022). Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy. ACS Nano, 16(9), 13513-13553. https://dx.doi.org/10.1021/acsnano.2c05379
Project: NRF-NRFI2018-03 
Journal: ACS Nano 
Abstract: Prodrugs are chemically modified drug molecules that are inactive before administration. After administration, they are converted in situ to parent drugs and induce the mechanism of action. The development of prodrugs has upgraded conventional drug treatments in terms of bioavailability, targeting, and reduced side effects. Especially in cancer therapy, the application of prodrugs has achieved substantial therapeutic effects. From serendipitous discovery in the early stage to functional design with pertinence nowadays, the importance of prodrugs in drug design is self-evident. At present, studying stimuli-responsive activation mechanisms, regulating the stimuli intensity in vivo, and designing nanoscale prodrug formulations are the major strategies to promote the development of prodrugs. In this review, we provide an outlook of recent cutting-edge studies on stimuli-responsive prodrug nanosystems from these three aspects. We also discuss prospects and challenges in the future development of such prodrugs.
URI: https://hdl.handle.net/10356/165552
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c05379
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © 2022 American Chemical Society, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsnano.2c05379.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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