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https://hdl.handle.net/10356/165862
Title: | Protein-based biological materials: molecular design and artificial production | Authors: | Miserez, Ali Yu, Jing Mohammadi, Pezhman |
Keywords: | Science::Biological sciences | Issue Date: | 2023 | Source: | Miserez, A., Yu, J. & Mohammadi, P. (2023). Protein-based biological materials: molecular design and artificial production. Chemical Reviews, 123(5), 2049-2111. https://dx.doi.org/10.1021/acs.chemrev.2c00621 | Project: | MOE 2019-T3-1-012 MOE 2018-T2-1-043 NRFNRFF11-2019-0004 MOE-T2EP30220-0006 |
Journal: | Chemical Reviews | Abstract: | Polymeric materials produced from fossil fuels have been intimately linked to the development of industrial activities in the 20th century and, consequently, to the transformation of our way of living. While this has brought many benefits, the fabrication and disposal of these materials is bringing enormous sustainable challenges. Thus, materials that are produced in a more sustainable fashion and whose degradation products are harmless to the environment are urgently needed. Natural biopolymers –which can compete and sometimes surpass the performance of synthetic polymers– provide a great source of inspiration. They are made of natural chemicals, under benign environmental conditions, and their degradation products are harmless. Before these materials can be synthetically replicated, it is essential to elucidate their chemical design and biofabrication. For protein-based materials, this means obtaining the complete sequences of the proteinaceous building blocks, a task that historically took decades of research. Thus, we start the review with a historical perspective on early efforts to obtain the primary sequences of load-bearing proteins, followed by latest developments in sequencing and proteomic technologies that have greatly accelerated sequencing of extracellular proteins. Next, four main classes of protein materials are presented, namely fibrous materials, bioelastomers exhibiting high reversible deformability, hard bulk materials, and biological adhesives. In each class, we focus on the design at the primary and secondary structure levels and discuss their interplays with the mechanical response. We finally discuss earlier and latest research to artificially produce protein-based materials using biotechnology and synthetic biology, including current developments by start-up companies to scale-up the production of proteinaceous materials in an economically viable manner. | URI: | https://hdl.handle.net/10356/165862 | ISSN: | 0009-2665 | DOI: | 10.1021/acs.chemrev.2c00621 | Schools: | School of Materials Science and Engineering | Rights: | © 2023 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Journal Articles |
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acs.chemrev.2c00621.pdf | 35.64 MB | Adobe PDF | ![]() View/Open |
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