Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/165862
Title: Protein-based biological materials: molecular design and artificial production
Authors: Miserez, Ali
Yu, Jing
Mohammadi, Pezhman
Keywords: Science::Biological sciences
Issue Date: 2023
Source: Miserez, A., Yu, J. & Mohammadi, P. (2023). Protein-based biological materials: molecular design and artificial production. Chemical Reviews, 123(5), 2049-2111. https://dx.doi.org/10.1021/acs.chemrev.2c00621
Project: MOE 2019-T3-1-012 
MOE 2018-T2-1-043 
NRFNRFF11-2019-0004 
MOE-T2EP30220-0006 
Journal: Chemical Reviews 
Abstract: Polymeric materials produced from fossil fuels have been intimately linked to the development of industrial activities in the 20th century and, consequently, to the transformation of our way of living. While this has brought many benefits, the fabrication and disposal of these materials is bringing enormous sustainable challenges. Thus, materials that are produced in a more sustainable fashion and whose degradation products are harmless to the environment are urgently needed. Natural biopolymers –which can compete and sometimes surpass the performance of synthetic polymers– provide a great source of inspiration. They are made of natural chemicals, under benign environmental conditions, and their degradation products are harmless. Before these materials can be synthetically replicated, it is essential to elucidate their chemical design and biofabrication. For protein-based materials, this means obtaining the complete sequences of the proteinaceous building blocks, a task that historically took decades of research. Thus, we start the review with a historical perspective on early efforts to obtain the primary sequences of load-bearing proteins, followed by latest developments in sequencing and proteomic technologies that have greatly accelerated sequencing of extracellular proteins. Next, four main classes of protein materials are presented, namely fibrous materials, bioelastomers exhibiting high reversible deformability, hard bulk materials, and biological adhesives. In each class, we focus on the design at the primary and secondary structure levels and discuss their interplays with the mechanical response. We finally discuss earlier and latest research to artificially produce protein-based materials using biotechnology and synthetic biology, including current developments by start-up companies to scale-up the production of proteinaceous materials in an economically viable manner.
URI: https://hdl.handle.net/10356/165862
ISSN: 0009-2665
DOI: 10.1021/acs.chemrev.2c00621
Schools: School of Materials Science and Engineering 
Rights: © 2023 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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