Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/16589
Title: Identification of biomarker in patients on low dose warfarin : an iTRAQ-coupled LC-MS/MS approach
Authors: Koh, Regina Hwee Chen.
Keywords: DRNTU::Engineering::Chemical engineering::Biotechnology
Issue Date: 2009
Abstract: Warfarin is one of the most widely used oral anticoagulant. However, the dosage of warfarin given to patients is very critical as an overdose may lead to severe bleeding or an under-dosing may lead to clotting of the blood. Hence, it is important to find clues and leads to enable medical professionals to determine if individual patients are to be on high or low dose warfarin requirements. The search for protein biomarkers which helps to differentiate patients on low-dose warfarin requirement from those on high-dose warfarin requirement is the aim and target of this project. An iTRAQ coupled LC-MS/MS approach will be taken to determine the protein biomarker. From present and past results obtained, TP, a protein biomarker has been found significant in patients on low-dose warfarin and is absent in all high-dose warfarin patients. This observation has led us to determine this protein as our target protein biomarker for patients who are on low-dose warfarin requirement. This finding could potentially minimize the risk of over-dose during warfarin induction.
URI: http://hdl.handle.net/10356/16589
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
KohReginaHweeChen09.pdf
  Restricted Access
811.75 kBAdobe PDFView/Open

Page view(s) 20

281
Updated on Nov 25, 2020

Download(s) 20

6
Updated on Nov 25, 2020

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.