Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/166436
Title: Label-free plasmonic-based biosensing using a gold nanohole array chip coated with a wafer-scale deposited WS₂ monolayer
Authors: Kang, Lixing
Zhang, Yan
Gong, Qian
Das, Chandreyee Manas
Shao, Huilin
Poenar, Daniel Puiu
Coquet, Philippe
Yong, Ken-Tye
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2022
Source: Kang, L., Zhang, Y., Gong, Q., Das, C. M., Shao, H., Poenar, D. P., Coquet, P. & Yong, K. (2022). Label-free plasmonic-based biosensing using a gold nanohole array chip coated with a wafer-scale deposited WS₂ monolayer. RSC Advances, 12(51), 33284-33292. https://dx.doi.org/10.1039/d2ra03479d
Project: NRF2017-NRF-ANR002 2DPS 
Journal: RSC Advances 
Abstract: This paper reports the fabrication, testing and obtained performance of a plasmonic sensor employing a gold (Au) nanohole array chip coated with tungsten disulphide (WS2), which is then functionalized for the detection of protein-protein interactions. A key novelty is that the WS2 was deposited as a monoatomic layer using a wafer-scale synthesis method that successfully provided a film of both high quality and uniform thickness. The deposited WS2 film was transferred onto a Au nanohole array chip using a novel method and was subsequently functionalized with biotin. The final sensor was tested and it demonstrated efficient real-time and label-free plasmonic detection of biotin-streptavidin coupling. Specifically, compared to a standard (i.e. uncoated) Au nanohole-based sensor, our WS2-coated Au nanohole array boosted the spectral shift of the resonance wavelength by ∼190%, resulting in a 7.64-fold improvement of the limit of detection (LOD).
URI: https://hdl.handle.net/10356/166436
ISSN: 2046-2069
DOI: 10.1039/d2ra03479d
Schools: School of Electrical and Electronic Engineering 
Research Centres: CNRS International NTU THALES Research Alliances 
Rights: © 2022 The Author(s). Published by the Royal Society of Chemistry. All rights reserved. This paper was published in RSC Advances and is made available with permission of The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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