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https://hdl.handle.net/10356/166436
Title: | Label-free plasmonic-based biosensing using a gold nanohole array chip coated with a wafer-scale deposited WS₂ monolayer | Authors: | Kang, Lixing Zhang, Yan Gong, Qian Das, Chandreyee Manas Shao, Huilin Poenar, Daniel Puiu Coquet, Philippe Yong, Ken-Tye |
Keywords: | Engineering::Electrical and electronic engineering | Issue Date: | 2022 | Source: | Kang, L., Zhang, Y., Gong, Q., Das, C. M., Shao, H., Poenar, D. P., Coquet, P. & Yong, K. (2022). Label-free plasmonic-based biosensing using a gold nanohole array chip coated with a wafer-scale deposited WS₂ monolayer. RSC Advances, 12(51), 33284-33292. https://dx.doi.org/10.1039/d2ra03479d | Project: | NRF2017-NRF-ANR002 2DPS | Journal: | RSC Advances | Abstract: | This paper reports the fabrication, testing and obtained performance of a plasmonic sensor employing a gold (Au) nanohole array chip coated with tungsten disulphide (WS2), which is then functionalized for the detection of protein-protein interactions. A key novelty is that the WS2 was deposited as a monoatomic layer using a wafer-scale synthesis method that successfully provided a film of both high quality and uniform thickness. The deposited WS2 film was transferred onto a Au nanohole array chip using a novel method and was subsequently functionalized with biotin. The final sensor was tested and it demonstrated efficient real-time and label-free plasmonic detection of biotin-streptavidin coupling. Specifically, compared to a standard (i.e. uncoated) Au nanohole-based sensor, our WS2-coated Au nanohole array boosted the spectral shift of the resonance wavelength by ∼190%, resulting in a 7.64-fold improvement of the limit of detection (LOD). | URI: | https://hdl.handle.net/10356/166436 | ISSN: | 2046-2069 | DOI: | 10.1039/d2ra03479d | Schools: | School of Electrical and Electronic Engineering | Research Centres: | CNRS International NTU THALES Research Alliances | Rights: | © 2022 The Author(s). Published by the Royal Society of Chemistry. All rights reserved. This paper was published in RSC Advances and is made available with permission of The Author(s). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | EEE Journal Articles |
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PaperWS2plasmonicSensor-v10.pdf | 4.77 MB | Adobe PDF | ![]() View/Open |
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