Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/166597
Title: Functional dissection of membrane contacts sites in neuronal health in C. elegans
Authors: Nur Raihanah Binte Mohd Harion
Keywords: Science::Biological sciences::Molecular biology
Science::Biological sciences::Genetics
Issue Date: 2023
Publisher: Nanyang Technological University
Source: Nur Raihanah Binte Mohd Harion (2023). Functional dissection of membrane contacts sites in neuronal health in C. elegans. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/166597
Abstract: In neurons, the endoplasmic reticulum (ER) extends throughout all cellular processes, forming multiple contacts with the plasma membrane (PM) to fine-tune neuronal physiology. In my thesis project, I used the C. elegans DA9 motor neuron as my model system to explore the molecular mechanisms that are responsible for maintaining the distribution and function of neuronal ER-PM contact sites. I find that CIL-1 and ATLN-1 act together to maintain the somatodendritic enrichment of neuronal ER-PM contacts. Further, I show that the non-uniform distribution of ER-PM contact sites regulated by these proteins might be essential for efficient axon regeneration following a damaging insult. Finally, I provide evidence that ZC328.3 (the sole C. elegans homolog of GRAMD1 proteins, evolutionarily conserved sterol transporters that act at ER-PM contact sites) may contribute to cholesterol homeostasis in neurons. Collectively, my studies suggest that the maintenance of ER-PM contact sites is critical for maintaining neuronal health.
URI: https://hdl.handle.net/10356/166597
DOI: 10.32657/10356/166597
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20250501
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Theses

Files in This Item:
File Description SizeFormat 
FUNCTIONAL DISSECTION OF MEMBRANE CONTACTS SITES IN NEURONAL HEALTH IN C. elegans.pdf
  Until 2025-05-01
51.79 MBAdobe PDFUnder embargo until May 01, 2025

Page view(s)

209
Updated on Apr 17, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.