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dc.contributor.authorNur Raihanah Binte Mohd Harionen_US
dc.date.accessioned2023-05-08T02:39:26Z-
dc.date.available2023-05-08T02:39:26Z-
dc.date.issued2023-
dc.identifier.citationNur Raihanah Binte Mohd Harion (2023). Functional dissection of membrane contacts sites in neuronal health in C. elegans. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/166597en_US
dc.identifier.urihttps://hdl.handle.net/10356/166597-
dc.description.abstractIn neurons, the endoplasmic reticulum (ER) extends throughout all cellular processes, forming multiple contacts with the plasma membrane (PM) to fine-tune neuronal physiology. In my thesis project, I used the C. elegans DA9 motor neuron as my model system to explore the molecular mechanisms that are responsible for maintaining the distribution and function of neuronal ER-PM contact sites. I find that CIL-1 and ATLN-1 act together to maintain the somatodendritic enrichment of neuronal ER-PM contacts. Further, I show that the non-uniform distribution of ER-PM contact sites regulated by these proteins might be essential for efficient axon regeneration following a damaging insult. Finally, I provide evidence that ZC328.3 (the sole C. elegans homolog of GRAMD1 proteins, evolutionarily conserved sterol transporters that act at ER-PM contact sites) may contribute to cholesterol homeostasis in neurons. Collectively, my studies suggest that the maintenance of ER-PM contact sites is critical for maintaining neuronal health.en_US
dc.language.isoenen_US
dc.publisherNanyang Technological Universityen_US
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).en_US
dc.subjectScience::Biological sciences::Molecular biologyen_US
dc.subjectScience::Biological sciences::Geneticsen_US
dc.titleFunctional dissection of membrane contacts sites in neuronal health in C. elegansen_US
dc.typeThesis-Doctor of Philosophyen_US
dc.contributor.supervisorYasunori Sahekien_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.degreeDoctor of Philosophyen_US
dc.identifier.doi10.32657/10356/166597-
dc.contributor.supervisoremailyasunori.saheki@ntu.edu.sgen_US
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item.grantfulltextembargo_20250501-
Appears in Collections:LKCMedicine Theses
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