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Title: Functionalisation of extracellular vesicles for antibacterial applications
Authors: Puah, Ivan Wee Kiat
Keywords: Engineering::Materials::Biomaterials
Issue Date: 2023
Publisher: Nanyang Technological University
Source: Puah, I. W. K. (2023). Functionalisation of extracellular vesicles for antibacterial applications. Final Year Project (FYP), Nanyang Technological University, Singapore.
Abstract: Cell-derived nanovesicles (CDNs) mimic biological counterparts, exosomes, in the ability to accumulate at disease sites with specificity. This makes CDNs ideal for drug delivery and the targeting and therapeutic efficiency can be improve by functionalization of these vesicles with antibacterial properties. This project aims to utilise Pseudomonas aeruginosa bacteria-derived natural and mimetic extracellular vesicles (EVs) as a medium to stimulate live adipose-derived mesenchymal stem cells (ADSCs) to produce antimicrobial proteins, and using those stimulated ADSCs to produce mimetic ADSC-EVs that will contain antibacterial properties as a result of stimulation. In this study, the antibacterial activity of the stimulated mimetic ADSC-EVs was evaluated against normal mimetic ADSC-EVs and found to have improved antibacterial properties against Pseudomonas aeruginosa.
Schools: School of Materials Science and Engineering 
Fulltext Permission: embargo_restricted_20250412
Fulltext Availability: With Fulltext
Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)

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