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Title: Targeting the alphavirus virus replication process for antiviral development
Authors: Tan, Yaw Bia
Law, Michelle Cheok Yien
Luo, Dahai
Keywords: Science::Medicine
Science::Biological sciences
Issue Date: 2023
Source: Tan, Y. B., Law, M. C. Y. & Luo, D. (2023). Targeting the alphavirus virus replication process for antiviral development. Antiviral Research, 210, 105494-.
Project: MOE-T2EP30220- 0009
Journal: Antiviral Research
Abstract: Many alphaviruses, including chikungunya virus (CHIKV) are known human pathogens that lack specific and effective antivirals or vaccines available. The upstream portion of the positive-sense single-stranded RNA genome of alphaviruses encodes four nonstructural proteins: nsP1 to nsP4. They are expressed and autoprocessed to nonstructural proteins which assemble into a replication complex (RC) playing multiple essential roles on viral RNA replication and communication with the host components. The assembly of alphavirus RC and its RNA genome initiates the membrane-derived ultrastructure known as spherule which facilitates viral RNA synthesis protected from host immune responses. Recent advances in the molecular understanding of the high-resolution CHIKV RC heteromeric ultrastructure have provided new insights into the viral replication process. Hence, alphavirus RC presents as an ideal multi-enzyme target for the development of structure-based antiviral drugs. Moreover, the alphavirus RC has therapeutic potential in the form of self-amplifying RNA technology against both infectious and non-infectious diseases.
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2022.105494
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: NTU Institute of Structural Biology 
Rights: © 2022 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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