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dc.contributor.authorWong, Eleanoren_US
dc.contributor.authorBertin, Nicolasen_US
dc.contributor.authorHebrard, Maximeen_US
dc.contributor.authorTirado-Magallanes, Robertoen_US
dc.contributor.authorBellis, Claireen_US
dc.contributor.authorLim, Weng Khongen_US
dc.contributor.authorChua, Chee Yongen_US
dc.contributor.authorTong, Philomena Mei Linen_US
dc.contributor.authorChua, Raymonden_US
dc.contributor.authorMak, Kennethen_US
dc.contributor.authorLim, Tit Mengen_US
dc.contributor.authorCheong, Wei Yangen_US
dc.contributor.authorThien, Kwee Engen_US
dc.contributor.authorGoh, Khean Teiken_US
dc.contributor.authorChai, Jin-Fangen_US
dc.contributor.authorLee, Jimmyen_US
dc.contributor.authorSung, Joseph Jao Yiuen_US
dc.contributor.authorWong, Tien Yinen_US
dc.contributor.authorChin, Calvin Woon Loongen_US
dc.contributor.authorGluckman, Peter D.en_US
dc.contributor.authorGoh, Liuh Lingen_US
dc.contributor.authorBan, Kenneth Hon Kimen_US
dc.contributor.authorTan, Tin Weeen_US
dc.contributor.authorSim, Xuelingen_US
dc.contributor.authorCheng, Ching-Yuen_US
dc.contributor.authorDavila, Soniaen_US
dc.contributor.authorKarnani, Neerjaen_US
dc.contributor.authorLeong, Khai Pangen_US
dc.contributor.authorLiu, Jianjunen_US
dc.contributor.authorPrabhakar, Shyamen_US
dc.contributor.authorMaurer-Stroh, Sebastianen_US
dc.contributor.authorVerma, Chandra Shekharen_US
dc.contributor.authorKrishnaswamy, Pavitraen_US
dc.contributor.authorGoh, Rick Siow Mongen_US
dc.contributor.authorChia, Irenaeusen_US
dc.contributor.authorHo, Clarissaen_US
dc.contributor.authorLow, Doreenen_US
dc.contributor.authorVirabhak, Suchinen_US
dc.contributor.authorYong, Jacklynen_US
dc.contributor.authorZheng, Weilingen_US
dc.contributor.authorSeow, Shih Weeen_US
dc.contributor.authorSeck, Yee Kwangen_US
dc.contributor.authorKoh, Mingshien_US
dc.contributor.authorChambers, John Campbellen_US
dc.contributor.authorTai, E. Shyongen_US
dc.contributor.authorTan, Patricken_US
dc.identifier.citationWong, E., Bertin, N., Hebrard, M., Tirado-Magallanes, R., Bellis, C., Lim, W. K., Chua, C. Y., Tong, P. M. L., Chua, R., Mak, K., Lim, T. M., Cheong, W. Y., Thien, K. E., Goh, K. T., Chai, J., Lee, J., Sung, J. J. Y., Wong, T. Y., Chin, C. W. L., ...Tan, P. (2023). The Singapore national precision medicine strategy. Nature Genetics, 55(2), 178-186.
dc.description.abstractPrecision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world's population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Health (MOH)en_US
dc.description.sponsorshipNational Medical Research Council (NMRC)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofNature Geneticsen_US
dc.rights© 2023 Springer Nature America, Inc. All rights reserved.en_US
dc.titleThe Singapore national precision medicine strategyen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.subject.keywordsClinical Practiceen_US
dc.description.acknowledgementWe thank all investigators, staf members and study participants of the contributing cohorts and studies: (1) the HELIOS study at the Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; (2) the GUSTO study jointly hosted by the National University Hospital, KK Women’s and Children’s Hospital, the National University of Singapore and the Singapore Institute for Clinical Sciences, the Agency for Science Technology and Research (A*STAR); (3) the SEED cohort at the Singapore Eye Research Institute; (4) the MEC, National University of Singapore; (5) the PRISM cohort; and (6) the TTSH Personalised Medicine Normal Controls cohort. We also thank the National Supercomputing Centre, Singapore ( for computation resources. The SG10K_Health project is funded by the Industry Alignment Fund (Pre-Positioning) (IAF-PP, H17/01/a0/007); the project made use of participating study cohorts supported by the following funding sources: (1) the HELIOS study by grants from a Strategic Initiative at Lee Kong Chian School of Medicine, the Singapore MOH under its Singapore Translational Research Investigator Award (NMRC/STaR/0028/2017) and the IAF-PP (H18/01/a0/016); (2) the GUSTO study by the Singapore National Research Foundation under its Translational and Clinical Research Flagship Program and administered by the Singapore MOH’s National Medical Research Council Singapore (NMRC/TCR/004-NUS/2008, NMRC/ TCR/012-NUHS/2014) with additional funding support available through the A*STAR and the IAF-PP (H17/01/a0/005); (3) the SEED study by NMRC/CIRG/1417/2015, NMRC/CIRG/1488/2018 and NMRC/OFLCG/004/2018; (4) the MEC by individual research and clinical scientist award schemes from the Singapore National Medical Research Council (including MOH-000271-00) and the Singapore Biomedical Research Council, the Singapore MOH, the National University of Singapore and the Singapore National University Health System; (5) the PRISM cohort study by NMRC/CG/ M006/2017_NHCS, NMRC/STaR/0011/2012, NMRC/STaR/0026/2015, the Lee Foundation and the Tanoto Foundation; and (6) the TTSH cohort study by NMRC/CG12AUG2017 and CGAug16M012. This research is also supported by the National Research Foundation Singapore under its NPM program Phase II funding (MOH-000588) and administered by the Singapore MOH’s National Medical Research Council.en_US
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