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Title: The Singapore national precision medicine strategy
Authors: Wong, Eleanor
Bertin, Nicolas
Hebrard, Maxime
Tirado-Magallanes, Roberto
Bellis, Claire
Lim, Weng Khong
Chua, Chee Yong
Tong, Philomena Mei Lin
Chua, Raymond
Mak, Kenneth
Lim, Tit Meng
Cheong, Wei Yang
Thien, Kwee Eng
Goh, Khean Teik
Chai, Jin-Fang
Lee, Jimmy
Sung, Joseph Jao Yiu
Wong, Tien Yin
Chin, Calvin Woon Loong
Gluckman, Peter D.
Goh, Liuh Ling
Ban, Kenneth Hon Kim
Tan, Tin Wee
Sim, Xueling
Cheng, Ching-Yu
Davila, Sonia
Karnani, Neerja
Leong, Khai Pang
Liu, Jianjun
Prabhakar, Shyam
Maurer-Stroh, Sebastian
Verma, Chandra Shekhar
Krishnaswamy, Pavitra
Goh, Rick Siow Mong
Chia, Irenaeus
Ho, Clarissa
Low, Doreen
Virabhak, Suchin
Yong, Jacklyn
Zheng, Weiling
Seow, Shih Wee
Seck, Yee Kwang
Koh, Mingshi
Chambers, John Campbell
Tai, E. Shyong
Tan, Patrick
Keywords: Science::Medicine
Issue Date: 2023
Source: Wong, E., Bertin, N., Hebrard, M., Tirado-Magallanes, R., Bellis, C., Lim, W. K., Chua, C. Y., Tong, P. M. L., Chua, R., Mak, K., Lim, T. M., Cheong, W. Y., Thien, K. E., Goh, K. T., Chai, J., Lee, J., Sung, J. J. Y., Wong, T. Y., Chin, C. W. L., ...Tan, P. (2023). The Singapore national precision medicine strategy. Nature Genetics, 55(2), 178-186.
Journal: Nature Genetics
Abstract: Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world's population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.
ISSN: 1061-4036
DOI: 10.1038/s41588-022-01274-x
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2023 Springer Nature America, Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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