Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/169534
Title: A concise synthesis of pyrrole-based drug candidates from α-hydroxyketones, 3-oxobutanenitrile, and anilines
Authors: Xia, Mengxin
Santoso, Mardi
Moussa, Ziad
Judeh, Zaher M. A.
Keywords: Engineering::Chemical engineering
Issue Date: 2023
Source: Xia, M., Santoso, M., Moussa, Z. & Judeh, Z. M. A. (2023). A concise synthesis of pyrrole-based drug candidates from α-hydroxyketones, 3-oxobutanenitrile, and anilines. Molecules, 28(3), 1265-. https://dx.doi.org/10.3390/molecules28031265
Project: NTU-SUG 
Journal: Molecules 
Abstract: A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug candidates, including COX-2 selective NSAID, antituberculosis lead candidates BM212, BM521, and BM533, as well as several analogues. This route has potential to obtain diverse libraries of these pyrrole candidates in a concise manner to develop optimum lead compounds.
URI: https://hdl.handle.net/10356/169534
ISSN: 1420-3049
DOI: 10.3390/molecules28031265
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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