Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/169704
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dc.contributor.authorAdav, Sunil S.en_US
dc.contributor.authorLeung, Ching Yungen_US
dc.contributor.authorNg, Kee Woeien_US
dc.date.accessioned2023-08-01T07:44:27Z-
dc.date.available2023-08-01T07:44:27Z-
dc.date.issued2023-
dc.identifier.citationAdav, S. S., Leung, C. Y. & Ng, K. W. (2023). Profiling of hair proteome revealed individual demographics. Forensic Science International: Genetics, 66, 102914-. https://dx.doi.org/10.1016/j.fsigen.2023.102914en_US
dc.identifier.issn1872-4973en_US
dc.identifier.urihttps://hdl.handle.net/10356/169704-
dc.description.abstractHuman hair is often found at crime scenes, persists for a long time, and is a valuable biological specimen in forensic investigations. Hair contains minimal intact nuclear DNA for the discrimination of individual identity. In such cases, proteomics evaluation of hair proteins could provide an attractive alternative for protein-based human identification. Therefore, this study adopted a proteomic approach to profile hair shafts from both males and females across different ethnic populations including Chinese, Indians, Malays, and Filipinos in their 20s-80s. First, hair proteins were extracted by different methods to adopt the most suitable protocol that produced the highest extraction efficiency based on most significant enrichment of keratins and keratin-associated proteins. Abundance of hair keratins including both types I and II, and keratin-associated proteins, estimated using label-free quantification, showed distinguishable profiles, and the possibilities of distinguishing individuals within each ethnic origin. Similarly, several protein candidates and their abundances could be used to distinguish sex and age of individuals. This study explored the possibility of utilizing hair proteomics phenotyping in forensic science to differentiate individuals across various ethnic groups, sex and age.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationAcRF Tier 1 RG7/22en_US
dc.relation.ispartofForensic Science International: Geneticsen_US
dc.rights© 2023 Elsevier B.V. All rights reserved.en_US
dc.subjectEngineering::Materialsen_US
dc.titleProfiling of hair proteome revealed individual demographicsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.researchNanyang Environment and Water Research Instituteen_US
dc.identifier.doi10.1016/j.fsigen.2023.102914-
dc.identifier.volume66en_US
dc.identifier.spage102914en_US
dc.subject.keywordsHair Shaften_US
dc.subject.keywordsHair Keratinsen_US
dc.subject.keywordsProteomicsen_US
dc.subject.keywordsForensic Scienceen_US
dc.subject.keywordsProtein Abundanceen_US
dc.description.acknowledgementThis work was supported by the Ministry of Education, Singapore (AcRF Tier 1 RG7/22).en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
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