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Title: Case report: olaparib use in metastatic lung adenocarcinoma with BRCA2 pathogenic variant
Authors: Soon, Jonathan Jian Hao
Chan, Sock Hoai
Tan, Daniel Shao Weng
Ngeow, Joanne
Chiang, Jianbang
Keywords: Science::Medicine
Issue Date: 2022
Source: Soon, J. J. H., Chan, S. H., Tan, D. S. W., Ngeow, J. & Chiang, J. (2022). Case report: olaparib use in metastatic lung adenocarcinoma with BRCA2 pathogenic variant. Cold Spring Harbor Molecular Case Studies, 8(7), a006223-.
Journal: Cold Spring Harbor Molecular Case Studies 
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors have been approved in malignancies associated with germline BRCA1 or BRCA2 pathogenic variants, such as breast, ovarian, prostate, and pancreatic cancer. In malignancies not associated with germline BRCA1 or BRCA2 pathogenic variants, the therapeutic relevance of PARP inhibitors is less clear. Non-small-cell lung cancer (NSCLC) is known to demonstrate somatic alterations in BRCA1 or BRCA2 gene. The current report is on a gentleman with metastatic lung adenocarcinoma with a somatic BRCA2 pathogenic variant, who was effectively treated with olaparib. Furthermore, we discuss the existing data for use of PARP inhibitors in NSCLC. This study highlights the utility of next-generation sequencing in identifying gene mutations and demonstrates how such information can be used to select targeted therapies in patients with actionable molecular alterations.
ISSN: 2373-2873
DOI: 10.1101/mcs.a006223
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Cancer Centre, Singapore 
Duke-NUS Medical School 
Institute of Molecular and Cellular Biology, A*STAR 
Rights: © 2022 Soon Jian Hao et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted reuse and redistribution provided that the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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