Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/170426
Title: Film-facilitated formation of ferrocenecarboxylic acid-embedded metal-organic framework nanoparticles for sonodynamic osteosarcoma treatment
Authors: Deng, Xiangyu
Guo, Yi
Zhang, Xiaodong
Wu, Wei
Wu, Yinglong
Jing, Doudou
Wang, Dongdong
Shao, Zengwu
Zhao, Yanli
Keywords: Science::Chemistry
Issue Date: 2022
Source: Deng, X., Guo, Y., Zhang, X., Wu, W., Wu, Y., Jing, D., Wang, D., Shao, Z. & Zhao, Y. (2022). Film-facilitated formation of ferrocenecarboxylic acid-embedded metal-organic framework nanoparticles for sonodynamic osteosarcoma treatment. Materials Today Chemistry, 24, 100842-. https://dx.doi.org/10.1016/j.mtchem.2022.100842
Project: A20E5c0081 
NRF-NRFI2018-03 
Journal: Materials Today Chemistry 
Abstract: Sonodynamic therapy (SDT) has stronger penetrating ability compared with phototherapy due to the replacement of excitant from near-infrared light to ultrasound. The effective combination of low-intensity ultrasound and sonosensitizers allows SDT to penetrate deep tissue for the treatment of deep solid tumors. In this research, hybrid metal-organic framework (MOF) nanoparticles (FcCOOH-ZnTCPP, FcCOOH: ferrocenecarboxylic acid, TCPP: tetra(4-carboxyphenyl)porphyrin) are synthesized by a simple film technology, demonstrating outstanding acoustic response characteristics. FcCOOH is directly embedded in the nanoparticles during the formation process of FcCOOH-ZnTCPP, where FcCOOH catalyzes excess hydrogen peroxide in the tumor microenvironment to oxygen for increasing the SDT effect. Hybrid MOF nanoparticles with good biocompatibility and internalization ability to tumor cells present enhanced therapeutic effect to osteosarcoma on account of synergistic contributions of ZnTCPP and FcCOOH. This FcCOOH-ZnTCPP system may pave a new way for precise and efficient tumor inhibition.
URI: https://hdl.handle.net/10356/170426
ISSN: 2468-5194
DOI: 10.1016/j.mtchem.2022.100842
Schools: School of Physical and Mathematical Sciences 
Rights: © 2022 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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