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Title: Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging
Authors: Wu, Yinglong
Sun, Lihe
Chen, Xiaokai
Liu, Jiawei
Ouyang, Juan
Zhang, Xiaodong
Guo, Yi
Chen, Yun
Yuan, Wei
Wang, Dongdong
He, Ting
Zeng, Fang
Chen, Hongzhong
Wu, Shuizhu
Zhao, Yanli
Keywords: Engineering::Bioengineering
Issue Date: 2023
Source: Wu, Y., Sun, L., Chen, X., Liu, J., Ouyang, J., Zhang, X., Guo, Y., Chen, Y., Yuan, W., Wang, D., He, T., Zeng, F., Chen, H., Wu, S. & Zhao, Y. (2023). Cucurbit[8]uril-based water-dispersible assemblies with enhanced optoacoustic performance for multispectral optoacoustic imaging. Nature Communications, 14(1), 3918-.
Project: A20E5c0081 
Journal: Nature Communications 
Abstract: Organic small-molecule contrast agents have attracted considerable attention in the field of multispectral optoacoustic imaging, but their weak optoacoustic performance resulted from relatively low extinction coefficient and poor water solubility restrains their widespread applications. Herein, we address these limitations by constructing supramolecular assemblies based on cucurbit[8]uril (CB[8]). Two dixanthene-based chromophores (DXP and DXBTZ) are synthesized as the model guest compounds, and then included in CB[8] to prepare host-guest complexes. The obtained DXP-CB[8] and DXBTZ-CB[8] display red-shifted and increased absorption as well as decreased fluorescence, thereby leading to a substantial enhancement in optoacoustic performance. Biological application potential of DXBTZ-CB[8] is investigated after co-assembly with chondroitin sulfate A (CSA). Benefiting from the excellent optoacoustic property of DXBTZ-CB[8] and the CD44-targeting feature of CSA, the formulated DXBTZ-CB[8]/CSA can effectively detect and diagnose subcutaneous tumors, orthotopic bladder tumors, lymphatic metastasis of tumors and ischemia/reperfusion-induced acute kidney injury in mouse models with multispectral optoacoustic imaging.
ISSN: 2041-1723
DOI: 10.1038/s41467-023-39610-2
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Rights: © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Journal Articles

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