Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/171048
Title: New mechanical markers for tracking the progression of myocardial infarction
Authors: Chang, Zhuo
Zhang, Jing
Liu, Yilun
Gao, Huajian
Xu, Guang-Kui
Keywords: Engineering::Mechanical engineering
Issue Date: 2023
Source: Chang, Z., Zhang, J., Liu, Y., Gao, H. & Xu, G. (2023). New mechanical markers for tracking the progression of myocardial infarction. Nano Letters, 23(16), 7350-7357. https://dx.doi.org/10.1021/acs.nanolett.3c01712
Project: 002479-00001 
Journal: Nano Letters 
Abstract: The mechanical properties of soft tissues can often be strongly correlated with the progression of various diseases, such as myocardial infarction (MI). However, the dynamic mechanical properties of cardiac tissues during MI progression remain poorly understood. Herein, we investigate the rheological responses of cardiac tissues at different stages of MI (i.e., early-stage, mid-stage, and late-stage) with atomic force microscopy-based microrheology. Surprisingly, we discover that all cardiac tissues exhibit a universal two-stage power-law rheological behavior at different time scales. The experimentally found power-law exponents can capture an inconspicuous initial rheological change, making them particularly suitable as markers for early-stage MI diagnosis. We further develop a self-similar hierarchical model to characterize the progressive mechanical changes from subcellular to tissue scales. The theoretically calculated mechanical indexes are found to markedly vary among different stages of MI. These new mechanical markers are applicable for tracking the subtle changes of cardiac tissues during MI progression.
URI: https://hdl.handle.net/10356/171048
ISSN: 1530-6984
DOI: 10.1021/acs.nanolett.3c01712
Schools: School of Mechanical and Aerospace Engineering 
Organisations: Institute of High Performance Computing, A*STAR 
Rights: © 2023 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY-NC-ND 4.0.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles

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