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Title: Sequence variants affecting voice pitch in humans
Authors: Gisladottir, Rosa S.
Helgason, Agnar
Halldorsson, Bjarni V.
Helgason, Hannes
Borsky, Michal
Chien, Yu-Ren
Gudnason, Jon
Gudjonsson, Sigurjon A.
Moisik, Scott
Dediu, Dan
Thorleifsson, Gudmar
Tragante, Vinicius
Bustamante, Mariana
Jonsdottir, Gudrun A.
Stefansdottir, Lilja
Rutsdottir, Gudrun
Magnusson, Sigurdur H.
Hardarson, Marteinn
Ferkingstad, Egil
Halldorsson, Gisli H.
Rognvaldsson, Solvi
Skuladottir, Astros
Ivarsdottir, Erna V.
Norddahl, Gudmundur
Thorgeirsson, Gudmundur
Jonsdottir, Ingileif
Ulfarsson, Magnus O.
Holm, Hilma
Stefansson, Hreinn
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F.
Sulem, Patrick
Stefansson, Kari
Keywords: Humanities::Linguistics
Issue Date: 2023
Source: Gisladottir, R. S., Helgason, A., Halldorsson, B. V., Helgason, H., Borsky, M., Chien, Y., Gudnason, J., Gudjonsson, S. A., Moisik, S., Dediu, D., Thorleifsson, G., Tragante, V., Bustamante, M., Jonsdottir, G. A., Stefansdottir, L., Rutsdottir, G., Magnusson, S. H., Hardarson, M., Ferkingstad, E., ...Stefansson, K. (2023). Sequence variants affecting voice pitch in humans. Science Advances, 9(23), eabq2969-.
Journal: Science Advances 
Abstract: The genetic basis of the human vocal system is largely unknown, as are the sequence variants that give rise to individual differences in voice and speech. Here, we couple data on diversity in the sequence of the genome with voice and vowel acoustics in speech recordings from 12,901 Icelanders. We show how voice pitch and vowel acoustics vary across the life span and correlate with anthropometric, physiological, and cognitive traits. We found that voice pitch and vowel acoustics have a heritable component and discovered correlated common variants in ABCC9 that associate with voice pitch. The ABCC9 variants also associate with adrenal gene expression and cardiovascular traits. By showing that voice and vowel acoustics are influenced by genetics, we have taken important steps toward understanding the genetics and evolution of the human vocal system.
ISSN: 2375-2548
DOI: 10.1126/sciadv.abq2969
Schools: School of Humanities 
Rights: © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SoH Journal Articles

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