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Title: Investigating the functions of alternatively spliced Kindlin-2
Authors: Wong, Jun Sheng
Keywords: Science::Biological sciences
Issue Date: 2023
Publisher: Nanyang Technological University
Source: Wong, J. S. (2023). Investigating the functions of alternatively spliced Kindlin-2. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Kindlins are cytoplasmic proteins that function as an important co-activator for integrin activation. They are important for cell adhesion and migration. In human, there are three paralogs of Kindlins, namely Kindlin-1, Kindlin-2 and Kindlin-3. In particular to Kindlin2, the canonical Kindlin-2 (K2S) is homogenously expressed in all tissues except cells of the hematopoietic lineage. Apart from the K2S, there are at least two known spliced isoforms, namely the isoform 2 long version (K2L) and isoform 3 truncated version (K2T). To date, the tissue distributions and functions of these spliced isoforms are not yet elucidated. In this thesis, we focus on unveiling the functions and potential interacting partners of K2L spliced isoform.
DOI: 10.32657/10356/171815
Schools: School of Biological Sciences 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20251109
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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