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Title: A lubricant and adhesive hydrogel cross-linked from hyaluronic acid and chitosan for articular cartilage regeneration
Authors: Qiu, Haofeng
Deng, Junjie
Wei, Rufang
Wu, Xiang
Chen, Shengjia
Yang, Yanyu
Gong, Chenyang
Cui, Lingling
Si, Zhangyong
Zhu, Yabin
Wang, Rong
Xiong, Dangsheng
Keywords: Engineering::Bioengineering
Issue Date: 2023
Source: Qiu, H., Deng, J., Wei, R., Wu, X., Chen, S., Yang, Y., Gong, C., Cui, L., Si, Z., Zhu, Y., Wang, R. & Xiong, D. (2023). A lubricant and adhesive hydrogel cross-linked from hyaluronic acid and chitosan for articular cartilage regeneration. International Journal of Biological Macromolecules, 243, 125249-.
Journal: International Journal of Biological Macromolecules 
Abstract: Trauma-induced articular cartilage damages are common in clinical practice. Hydrogels have been used to fill the cartilage defects and act as extracellular matrices for cell migration and tissue regeneration. Lubrication and stability of the filler materials are essential to achieve a satisfying healing effect in cartilage regeneration. However, conventional hydrogels failed to provide a lubricous effect, or could not anchor to the wound to maintain a stable curing effect. Herein, we fabricated dually cross-linked hydrogels using oxidized hyaluronic acid (OHA) and N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) methacrylate (HTCCMA). The OHA/HTCCMA hydrogels, which were dynamically cross-linked and then covalently cross-linked by photo-irradiation, showed appropriate rheological properties and self-healing capability. The hydrogels exhibited moderate and stable tissue adhesion property due to formation of dynamic covalent bonds with the cartilage surface. The coefficient of friction values were 0.065 and 0.078 for the dynamically cross-linked and double-cross-linked hydrogels, respectively, demonstrating superior lubrication. In vitro studies showed that the hydrogels had good antibacterial ability and promoted cell proliferation. In vivo studies confirmed that the hydrogels were biocompatible and biodegradable, and exhibited a robust regenerating ability for articular cartilage. This lubricant-adhesive hydrogel is expected to be promising for the treatment of joint injuries as well as regeneration.
ISSN: 0141-8130
DOI: 10.1016/j.ijbiomac.2023.125249
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2023 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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