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Title: Prolonged inflammation in patients hospitalized for coronavirus disease 2019 (COVID-19) resolves 2 years after infection
Authors: Fong, Siew-Wai
Goh, Yun Shan
Torres-Ruesta, Anthony
Chang, Zi Wei
Chan, Yi-Hao
Neo, Vanessa Kexin
Lee, Bernett
Duan, Kaibo
Amrun, Siti Naqiah
Yeo, Nicholas Kim-Wah
Chen, Hsiuyi V.
Tay, Matthew Zirui
Carissimo, Guillaume
Tan, Seow Yen
Leo, Yee Sin
Lye, David C.
Renia, Laurent
Young, Barnaby Edward
Ng, Lisa F. P.
Keywords: Science::Medicine
Issue Date: 2023
Source: Fong, S., Goh, Y. S., Torres-Ruesta, A., Chang, Z. W., Chan, Y., Neo, V. K., Lee, B., Duan, K., Amrun, S. N., Yeo, N. K., Chen, H. V., Tay, M. Z., Carissimo, G., Tan, S. Y., Leo, Y. S., Lye, D. C., Renia, L., Young, B. E. & Ng, L. F. P. (2023). Prolonged inflammation in patients hospitalized for coronavirus disease 2019 (COVID-19) resolves 2 years after infection. Journal of Medical Virology, 95(5), e28774-.
Project: COVID19RF-001 
Journal: Journal of Medical Virology 
Abstract: Long-term complications from coronavirus disease 2019 (COVID-19) are concerning, as survivors can develop subclinical multiorgan dysfunction. It is unknown if such complications are due to prolonged inflammation, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination may reduce sequela. We conducted a prospective longitudinal study on hospitalized patients over 24 months. Clinical symptoms were collected by self-reporting during follow-up, along with blood samples for quantification of inflammatory markers and immune cell frequencies. All patients were given one dose of mRNA vaccine at 12-16 months. Their immune profiles at 12 and 24 months were compared. Approximately 37% and 39% of our patients reported post-COVID-19 symptoms at 12 and 24 months, respectively. The proportion of symptomatic patients with more than one symptom decreased from 69% at 12 months to 56% at 24 months. Longitudinal cytokine profiling revealed a cluster of individuals with persistently high inflammatory cytokine levels 12 months after infection. Patients with prolonged inflammation showed elevated terminally differentiated memory T cells in their blood; 54% had symptoms at 12 months. The majority of inflammatory markers and dysregulated immune cells in vaccinated patients recovered to a healthy baseline at 24 months, even though symptoms persisted. Post-COVID-19 symptoms can linger for 2 years after the initial infection and are associated with prolonged inflammation. Prolonged inflammation in hospitalized patients resolves after 2 years. We define a set of analytes associated with persistent inflammation and presence of symptoms, which could be useful biomarkers for identifying and monitoring high-risk survivors.
ISSN: 0146-6615
DOI: 10.1002/jmv.28774
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: Singapore Immunology Network, A*STAR 
National Centre for Infectious Diseases, Singapore 
Tan Tock Seng Hospital 
Yong Loo Lin School of Medicine, NUS 
A*STAR Infectious Diseases Labs 
Rights: © 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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