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https://hdl.handle.net/10356/172169| Title: | APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia | Authors: | Vipin, Ashwati Kumar, Dilip Soo, See Ann Zailan, Fatin Zahra Leow, Yi Jin Koh, Chen Ling Ng, Adeline Su Lyn Ng, Kok Pin Kandiah, Nagaendran |
Keywords: | Science::Medicine | Issue Date: | 2023 | Source: | Vipin, A., Kumar, D., Soo, S. A., Zailan, F. Z., Leow, Y. J., Koh, C. L., Ng, A. S. L., Ng, K. P. & Kandiah, N. (2023). APOE4 carrier status determines association between white matter disease and grey matter atrophy in early-stage dementia. Alzheimer's Research & Therapy, 15(1), 103-. https://dx.doi.org/10.1186/s13195-023-01251-4 | Project: | MOE2017-T3-1–002 NMRC/CIRG/1415/2015 NMRC/CSA/063/2014 MOH-CSAINV18nov-0007 NMRC/CIRG/14MAY025 NNI-HREF-991016 |
Journal: | Alzheimer's Research & Therapy | Abstract: | White matter hyperintensities, a neuroimaging marker of small-vessel cerebrovascular disease and apolipoprotein ε4 (APOE4) allele, are important dementia risk factors. However, APOE4 as a key effect modifier in the relationship between white matter hyperintensities and grey matter volume needs further exploration. | URI: | https://hdl.handle.net/10356/172169 | ISSN: | 1758-9193 | DOI: | 10.1186/s13195-023-01251-4 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Research Centres: | Dementia Research Centre | Rights: | © 2023 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
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| s13195-023-01251-4.pdf | 1.48 MB | Adobe PDF |  View/Open |
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