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https://hdl.handle.net/10356/17218
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chew, Sing Yian. | - |
dc.date.accessioned | 2009-06-01T08:42:38Z | - |
dc.date.available | 2009-06-01T08:42:38Z | - |
dc.date.copyright | 2006 | en_US |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://hdl.handle.net/10356/17218 | - |
dc.description.abstract | This project embarked with the following specific aims: Synthesize and characterize electrospun scaffolds that are functionalized through the encapsulation of siRNA. a. Establish a robust system to incorporate and release siRNA in a sustained manner from poly(ε-caprolactone) (PCL) scaffolds made up of aligned and/ or randomly-oriented micro- and nano-fibers using electrospinning. b. Characterize the distribution; in vitro release kinetics; and bioactivity of the incorporated siRNA. c. Characterize the physical properties of electrospun scaffolds, such as scaffold morphology, and fiber diameter with respect to the inclusion of siRNA. d. Characterize the transfection efficiency of siRNA-encapsulated electrospun scaffolds with respect to the architecture of the scaffolds (scaffolds with aligned fibers vs. randomly-oriented fibers). | en_US |
dc.format.extent | 22 p. | en_US |
dc.language.iso | en | en_US |
dc.subject | DRNTU::Engineering::Chemical engineering::Biotechnology | en_US |
dc.title | RNA interference via sustained delivery of siRNA from electrospun fibrous scaffolds | en_US |
dc.type | Research Report | - |
dc.contributor.school | School of Chemical and Biomedical Engineering | en_US |
dc.description.reportnumber | RG 121/06 | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
Appears in Collections: | SCBE Research Reports (Staff & Graduate Students) |
Files in This Item:
File | Description | Size | Format | |
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ChewSingYian RG121-06 SCBE.pdf Restricted Access | 2.98 MB | Adobe PDF | View/Open |
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