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https://hdl.handle.net/10356/173012
Title: | Tunable Tamm plasmon cavity as a scalable biosensing platform for surface enhanced resonance Raman spectroscopy | Authors: | Sreekanth, Kandammathe Valiyaveedu Perumal, Jayakumar Dinish, U. S. Prabhathan, Patinharekandy Liu, Yuanda Singh, Ranjan Olivo, Malini Teng, Jinghua |
Keywords: | Science::Physics | Issue Date: | 2023 | Source: | Sreekanth, K. V., Perumal, J., Dinish, U. S., Prabhathan, P., Liu, Y., Singh, R., Olivo, M. & Teng, J. (2023). Tunable Tamm plasmon cavity as a scalable biosensing platform for surface enhanced resonance Raman spectroscopy. Nature Communications, 14(1), 7085-. https://dx.doi.org/10.1038/s41467-023-42854-7 | Project: | NRF-CRP23-2019-0005 | Journal: | Nature Communications | Abstract: | Surface enhanced Resonance Raman spectroscopy (SERRS) is a powerful technique for enhancing Raman spectra by matching the laser excitation wavelength with the plasmonic resonance and the absorption peak of biomolecules. Here, we propose a tunable Tamm plasmon polariton (TPP) cavity based on a metal on distributed Bragg reflector (DBR) as a scalable sensing platform for SERRS. We develop a gold film-coated ultralow-loss phase change material (Sb2S3) based DBR, which exhibits continuously tunable TPP resonances in the optical wavelengths. We demonstrate SERRS by matching the TPP resonance with the absorption peak of the chromophore molecule at 785 nm wavelength. We use this platform to detect cardiac Troponin I protein (cTnI), a biomarker for early diagnosis of cardiovascular disease, achieving a detection limit of 380 fM. This scalable substrate shows great promise as a next-generation tunable biosensing platform for detecting disease biomarkers in body fluids for routine real-time clinical diagnosis. | URI: | https://hdl.handle.net/10356/173012 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-023-42854-7 | Schools: | School of Physical and Mathematical Sciences | Research Centres: | Centre for Disruptive Photonic Technologies (CDPT) The Photonics Institute |
Rights: | © 2023 The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SPMS Journal Articles |
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s41467-023-42854-7.pdf | 1.64 MB | Adobe PDF | View/Open |
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