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https://hdl.handle.net/10356/174488| Title: | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma | Authors: | Mizokami, Harue Okabe, Atsushi Choudhary, Ruchi Mima, Masato Saeda, Kenta Fukuyo, Masaki Rahmutulla, Bahityar Seki, Motoaki Goh, Boon-Cher Kondo, Satoru Dochi, Hirotomo Moriyama-Kita, Makiko Misawa, Kiyoshi Hanazawa, Toyoyuki Tan, Patrick Yoshizaki, Tomokazu Fullwood, Melissa Jane Kaneda, Atsushi |
Keywords: | Medicine, Health and Life Sciences | Issue Date: | 2024 | Source: | Mizokami, H., Okabe, A., Choudhary, R., Mima, M., Saeda, K., Fukuyo, M., Rahmutulla, B., Seki, M., Goh, B., Kondo, S., Dochi, H., Moriyama-Kita, M., Misawa, K., Hanazawa, T., Tan, P., Yoshizaki, T., Fullwood, M. J. & Kaneda, A. (2024). Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma. EBioMedicine, 102, 105057-. https://dx.doi.org/10.1016/j.ebiom.2024.105057 | Project: | MOH000709 RG86/21 |
Journal: | eBioMedicine | Abstract: | Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermethylation. Epigenomic rewiring and enhancer dysregulation, such as enhancer hijacking due to genomic structural changes or extrachromosomal DNA, drive cancer progression. | URI: | https://hdl.handle.net/10356/174488 | ISSN: | 2352-3964 | DOI: | 10.1016/j.ebiom.2024.105057 | Schools: | School of Biological Sciences | Organisations: | Institute of Molecular and Cell Biology, A*STAR National University of Singapore |
Rights: | © 2024 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SBS Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| PIIS2352396424000926.pdf | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma | 4.4 MB | Adobe PDF |  View/Open |
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