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Title: Ferritin and gold based nanostructures for breast cancer photothermal therapy
Authors: Devrukhkar, Janhavi
Keywords: Medicine, Health and Life Sciences
Issue Date: 2024
Publisher: Nanyang Technological University
Source: Devrukhkar, J. (2024). Ferritin and gold based nanostructures for breast cancer photothermal therapy. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Photothermal therapy (PTT) has gained tremendous interest as a mode of minimally invasive localized cancer therapy for superficially situated tumours, thus avoiding the need for surgery, and preventing the side effects of chemotherapy. Gold nanoparticles have been extensively researched for their efficiency in photo-thermal therapy as photothermal agents. Gold nanocages, nanostars, nanorods as well as gold coated liposomes and polymers have been explored for their potential as photothermal agents. However, complex synthesis methods, large size, toxicity, poor stability and inefficient photothermal transduction ability are some of the shortcomings of these nanoparticles. Ferritin nanocages are preferred for biomedical applications due to the uniform size distribution, unique structure, and non-toxic nature. The design, synthesis, characterization, and in vitro studies of core shell ferritin and gold based nanostructures for application as theranostic agents is discussed in the thesis. Modified Ferritin nanocages were produced by well-established fermentation techniques in E coli and used for facile synthesis of small sized, near-infrared light responsive multifunctional gold and ferritin nanocomposites. The morphology allows the particles to be tuned to the NIR region of the electromagnetic spectra such that they dissipate heat in response to a continuous wave NIR diode laser. The in vitro studies reveal that synthesized nanoparticles are cytocompatible, haemocompatible and possess excellent photothermal transduction potential. These particles are useful candidates for cyclic photothermal therapy and show high cellular uptake and cell death due to photothermal effect on breast cancer cells at low laser power and low material concentration. As gold has a high atomic number, the particles can be used as contrast agents for computed tomography (CT) imaging showing diagnostic potential and for image guided photothermal therapy. The non-toxic nature, tumour ablation potential and system clearance was demonstrated in vivo. Photothermal efficacy study performed on breast cancer mouse xenograft model ascertained complete tumour ablation with a single dose of the nanoparticle formulation.
Schools: School of Chemistry, Chemical Engineering and Biotechnology 
Organisations: Indian Institute of Technology Bombay, India 
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
Fulltext Permission: embargo_20260523
Fulltext Availability: With Fulltext
Appears in Collections:CCEB Theses

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