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dc.contributor.authorWang, Yukunen_US
dc.contributor.authorChen, Sien_US
dc.contributor.authorChen, Xien_US
dc.contributor.authorXu, Zhengyangen_US
dc.contributor.authorLin, Kanen_US
dc.contributor.authorShi, Linlinen_US
dc.contributor.authorMu, Quanquanen_US
dc.contributor.authorLiu, Linboen_US
dc.identifier.citationWang, Y., Chen, S., Chen, X., Xu, Z., Lin, K., Shi, L., Mu, Q. & Liu, L. (2024). Coaxial bright and dark field optical coherence tomography. IEEE Transactions On Biomedical Engineering, 71(6), 1879-1888.
dc.description.abstractOptical coherence tomography (OCT) has been widely used in biomedicine. However, the signal collection efficiency of the standard OCT is sub-optimal since only the direct scattered light in the bright field is used. Almost 75% of multiple scattered light in the dark field is wasted. Here, we demonstrate a novel coaxial optical design that simultaneously collects bright and dark field signals. We implemented a wavefront-division beam splitter in the sample arm with a 45-degree rod mirror, which reflects the illumination. We detected light within its circular aperture in a way similar to the standard OCT and allowed the dark-field light of the annular-shaped aperture to pass and be collected by the dark-field detection channel. The bright and dark field signals are directed to the same spectrometer via a fiber array. With this scheme, multiple scattered light can be collected; the signal collection efficiency is improved by ~3dB for typical biological tissues. We demonstrate that the dark-field OCT images provide higher resolution and more information than the standard bright-field OCT, and compounding of bright and dark field images suppresses the speckles by ~√2. We validated these advantages with Teflon phantoms, chicken breast ex vivo, and human skin in vivo. We believe that this new configuration will greatly promote the OCT technique for biomedical applications.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofIEEE Transactions on Biomedical Engineeringen_US
dc.rights© 2024 IEEE. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at
dc.titleCoaxial bright and dark field optical coherence tomographyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.researchCenter for Biodevices & Bioinformaticsen_US
dc.contributor.researchCenter for Optical Fiber Technologyen_US
dc.contributor.researchCenter for Opto-Electronics & Biophotonicsen_US
dc.description.versionSubmitted/Accepted versionen_US
dc.subject.keywordsOptical coherence tomographyen_US
dc.subject.keywordsBright and dark field imagingen_US
dc.description.acknowledgementThis work was supported in part by the Singapore Ministry of Health’s National Medical Research Council under its Open Fund Individual Research under Grant MOH-000384, in part by the Singapore Ministry of Education under its Academic Research Funding Tier 2 under Grant MOE-T2EP30120–0001, in part by the China-Singapore International Joint Research Institute under Grant 203-A022001, in in part by the Academic Research Funding Tier 1 under Grant RG35/22, and in part by the China Scholarship Council, and the National Natural Science Foundation of China under Grant 12004381.en_US
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