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Title: Coaxial bright and dark field optical coherence tomography
Authors: Wang, Yukun
Chen, Si
Chen, Xi
Xu, Zhengyang
Lin, Kan
Shi, Linlin
Mu, Quanquan
Liu, Linbo
Keywords: Engineering
Issue Date: 2024
Source: Wang, Y., Chen, S., Chen, X., Xu, Z., Lin, K., Shi, L., Mu, Q. & Liu, L. (2024). Coaxial bright and dark field optical coherence tomography. IEEE Transactions On Biomedical Engineering, 71(6), 1879-1888.
Project: MOE-T2EP30120–0001 
Journal: IEEE Transactions on Biomedical Engineering 
Abstract: Optical coherence tomography (OCT) has been widely used in biomedicine. However, the signal collection efficiency of the standard OCT is sub-optimal since only the direct scattered light in the bright field is used. Almost 75% of multiple scattered light in the dark field is wasted. Here, we demonstrate a novel coaxial optical design that simultaneously collects bright and dark field signals. We implemented a wavefront-division beam splitter in the sample arm with a 45-degree rod mirror, which reflects the illumination. We detected light within its circular aperture in a way similar to the standard OCT and allowed the dark-field light of the annular-shaped aperture to pass and be collected by the dark-field detection channel. The bright and dark field signals are directed to the same spectrometer via a fiber array. With this scheme, multiple scattered light can be collected; the signal collection efficiency is improved by ~3dB for typical biological tissues. We demonstrate that the dark-field OCT images provide higher resolution and more information than the standard bright-field OCT, and compounding of bright and dark field images suppresses the speckles by ~√2. We validated these advantages with Teflon phantoms, chicken breast ex vivo, and human skin in vivo. We believe that this new configuration will greatly promote the OCT technique for biomedical applications.
ISSN: 0018-9294
DOI: 10.1109/TBME.2024.3355174
Schools: School of Electrical and Electronic Engineering 
Research Centres: Center for Biodevices & Bioinformatics
Center for Optical Fiber Technology
Center for Opto-Electronics & Biophotonics
Rights: © 2024 IEEE. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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