Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/179274
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dc.contributor.authorLi, Haopengen_US
dc.contributor.authorQian, Xuliangen_US
dc.contributor.authorMohanram, Harinien_US
dc.contributor.authorHan, Xiaoen_US
dc.contributor.authorQi, Huitangen_US
dc.contributor.authorZou, Guijinen_US
dc.contributor.authorYuan, Fenghouen_US
dc.contributor.authorMiserez, Alien_US
dc.contributor.authorLiu, Tianen_US
dc.contributor.authorYang, Qingen_US
dc.contributor.authorGao, Huajianen_US
dc.contributor.authorYu, Jingen_US
dc.date.accessioned2024-07-24T05:56:49Z-
dc.date.available2024-07-24T05:56:49Z-
dc.date.issued2024-
dc.identifier.citationLi, H., Qian, X., Mohanram, H., Han, X., Qi, H., Zou, G., Yuan, F., Miserez, A., Liu, T., Yang, Q., Gao, H. & Yu, J. (2024). Self-assembly of peptide nanocapsules by a solvent concentration gradient. Nature Nanotechnology, 19, 1141-1149. https://dx.doi.org/10.1038/s41565-024-01654-wen_US
dc.identifier.issn1748-3387en_US
dc.identifier.urihttps://hdl.handle.net/10356/179274-
dc.description.abstractBiological systems can create materials with intricate structures and specialized functions. In comparison, precise control of structures in human-made materials has been challenging. Here we report on insect cuticle peptides that spontaneously form nanocapsules through a single-step solvent exchange process, where the concentration gradient resulting from the mixing of water and acetone drives the localization and self-assembly of the peptides into hollow nanocapsules. The underlying driving force is found to be the intrinsic affinity of the peptides for a particular solvent concentration, while the diffusion of water and acetone creates a gradient interface that triggers peptide localization and self-assembly. This gradient-mediated self-assembly offers a transformative pathway towards simple generation of drug delivery systems based on peptide nanocapsules.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationMOE-T2EP30220-0006en_US
dc.relationMOE 2019-T3-1-012en_US
dc.relationMOE-MOET32022-0002en_US
dc.relationNRFF11-2019-0004en_US
dc.relationRG138/20en_US
dc.relationRG135/22en_US
dc.relation.ispartofNature Nanotechnologyen_US
dc.rights© 2024 The Author(s), under exclusive licence to Springer Nature Limited. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1038/s41565-024-01654-w.en_US
dc.subjectEngineeringen_US
dc.titleSelf-assembly of peptide nanocapsules by a solvent concentration gradienten_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.organizationInstitute of High Performance Computing, A*STARen_US
dc.contributor.researchBiological & Biomimetic Material Laboratory @ NTUen_US
dc.contributor.researchCenter for Sustainable Materialsen_US
dc.contributor.researchInstitute for Digital Molecular Analytics and Scienceen_US
dc.identifier.doi10.1038/s41565-024-01654-w-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.pmid38671050-
dc.identifier.scopus2-s2.0-85191723843-
dc.identifier.volume19en_US
dc.identifier.spage1141en_US
dc.identifier.epage1149en_US
dc.subject.keywordsAcetoneen_US
dc.subject.keywordsTargeted drug deliveryen_US
dc.description.acknowledgementH.L., X.H. and J.Y acknowledge support from the Singapore National Research Fellowship (NRF-NRFF11-2019-0004) and the Singapore Ministry of Education (MOE) Tier 2 Grant (MOE-T2EP30220-0006). T.L. acknowledges support from the National Natural Science Foundation of China (31871959) and the National Key R&D Program of China (2022YFD1700200). Q.Y. acknowledges support from the National Natural Science Foundation of China (32161133010), the National Key R&D Program of China (2022YFD1700200) and the Shenzhen Science and Technology Program (KQTD20180411143628272). X.Q. and H.G. acknowledge support from the Singapore Ministry of Education (MOE) under its Academic Research Fund Tier 1 award no. RG138/20, no. RG135/22 and a start-up grant from Nanyang Technological University, Singapore and A*STAR, Singapore. G.Z and H.G. acknowledge funding support from the Ministry of Education in Singapore under grant MOE-MOET32022-0002. A.M. acknowledges support from the Singapore Ministry of Education (MOE) through an Academic Research (AcRF) Tier 3 grant (Grant No. MOE 2019-T3-1-012). We acknowledge the Facility for Analysis, Characterisation, Testing and Simulation (FACTS) and NTU Institute of Structural Biology (NISB), Nanyang Technological University, Singapore, for use of their HR-TEM, Cryo-TEM and NMR facilities. Molecular dynamics simulations reported were performed on resources provided by the High Performance Computing Centre at Nanyang Technological University, Singapore, and the National Supercomputing Centre, Singapore ( http://www.nscc.sg ).en_US
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