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https://hdl.handle.net/10356/179681| Title: | Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells | Authors: | Ghiasi, Seyed M. Marchetti, Piero Piemonti, Lorenzo Nielsen, Jens H. Porse, Bo T. Mandrup-Poulsen, Thomas Rutter, Guy A. |
Keywords: | Medicine, Health and Life Sciences | Issue Date: | 2024 | Source: | Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, J. H., Porse, B. T., Mandrup-Poulsen, T. & Rutter, G. A. (2024). Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells. Frontiers in Endocrinology, 15, 1359147-. https://dx.doi.org/10.3389/fendo.2024.1359147 | Journal: | Frontiers in Endocrinology | Abstract: | Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. Here, we investigate whether cytokines regulate NMD activity and identify transcript isoforms targeted in ß cells. | URI: | https://hdl.handle.net/10356/179681 | ISSN: | 1664-2392 | DOI: | 10.3389/fendo.2024.1359147 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2024 Ghiasi, Marchetti, Piemonti, Nielsen, Porse, Mandrup-Poulsen and Rutter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| fendo-15-1359147.pdf | 3.92 MB | Adobe PDF |  View/Open |
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