Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/180337
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChen, Zhiqingen_US
dc.contributor.authorXie, Xiaopanen_US
dc.contributor.authorJia, Chunyanen_US
dc.contributor.authorZhong, Qishuoen_US
dc.contributor.authorZhang, Qiupingen_US
dc.contributor.authorLuo, Daoxinen_US
dc.contributor.authorCao, Yinen_US
dc.contributor.authorMu, Yuguangen_US
dc.contributor.authorRen, Changliangen_US
dc.date.accessioned2024-10-02T02:23:33Z-
dc.date.available2024-10-02T02:23:33Z-
dc.date.issued2024-
dc.identifier.citationChen, Z., Xie, X., Jia, C., Zhong, Q., Zhang, Q., Luo, D., Cao, Y., Mu, Y. & Ren, C. (2024). Concentration-driven evolution of adaptive artificial ion channels or nanopores with specific anticancer activities. Angewandte Chemie (International Ed. in English), 63(17), e202318811-. https://dx.doi.org/10.1002/anie.202318811en_US
dc.identifier.issn1433-7851en_US
dc.identifier.urihttps://hdl.handle.net/10356/180337-
dc.description.abstractIn nature, ceramides are a class of sphingolipids possessing a unique ability to self-assemble into protein-permeable channels with intriguing concentration-dependent adaptive channel cavities. However, within the realm of artificial ion channels, this interesting phenomenon is scarcely represented. Herein, we report on a novel class of adaptive artificial channels, Pn-TPPs, based on PEGylated cholic acids bearing triphenylphosphonium (TPP) groups as anion binding motifs. Interestingly, the molecules self-assemble into chloride ion channels at low concentrations while transforming into small molecule-permeable nanopores at high concentrations. Moreover, the TPP groups endow the molecules with mitochondria-targeting properties, enabling them to selectively drill holes on the mitochondrial membrane of cancer cells and subsequently trigger the caspase 9 apoptotic pathway. The anticancer efficacies of Pn-TPPs correlate with their abilities to form nanopores. Significantly, the most active ensembles formed by P5-TPP exhibits impressive anticancer activity against human liver cancer cells, with an IC50 value of 3.8 μM. While demonstrating similar anticancer performance to doxorubicin, P5-TPP exhibits a selectivity index surpassing that of doxorubicin by a factor of 16.8.en_US
dc.language.isoenen_US
dc.relation.ispartofAngewandte Chemie (International ed. in English)en_US
dc.rights© 2024 Wiley-VCH GmbH. All rights reserved.en_US
dc.subjectMedicine, Health and Life Sciencesen_US
dc.titleConcentration-driven evolution of adaptive artificial ion channels or nanopores with specific anticancer activitiesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.1002/anie.202318811-
dc.identifier.pmid38419371-
dc.identifier.scopus2-s2.0-85187948209-
dc.identifier.issue17en_US
dc.identifier.volume63en_US
dc.identifier.spagee202318811en_US
dc.subject.keywordsArtificial ion channelsen_US
dc.subject.keywordsChloride transporten_US
dc.description.acknowledgementThis work was supported by the National Natural Science Foundation of China (22271240 to C.R.), Science, Technology and Innovation Commission of Shenzhen Municipality(JCYJ20210324123411030 and JCYJ20220530143206013 to C.R.) and Nanqiang Youth Scholar Program of Xiamen University.en_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:SBS Journal Articles

SCOPUSTM   
Citations 50

6
Updated on Dec 4, 2024

Page view(s)

37
Updated on Dec 9, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.