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DC Field | Value | Language |
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dc.contributor.author | Lyu, Zipan | en_US |
dc.contributor.author | Chan, Yau-Tuen | en_US |
dc.contributor.author | Lu, Yuanjun | en_US |
dc.contributor.author | Lam, Tsz Fung | en_US |
dc.contributor.author | Wu, Xingyao | en_US |
dc.contributor.author | Wu, Junyu | en_US |
dc.contributor.author | Xu, Lin | en_US |
dc.contributor.author | Yang, Wei | en_US |
dc.contributor.author | Zhang, Cheng | en_US |
dc.contributor.author | Zhong, Linda Lidan | en_US |
dc.contributor.author | Wang, Ning | en_US |
dc.date.accessioned | 2024-10-09T08:00:35Z | - |
dc.date.available | 2024-10-09T08:00:35Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Lyu, Z., Chan, Y., Lu, Y., Lam, T. F., Wu, X., Wu, J., Xu, L., Yang, W., Zhang, C., Zhong, L. L. & Wang, N. (2024). Osteoprotegerin mediates adipogenesis in obesity. Journal of Advanced Research, 62, 245-255. https://dx.doi.org/10.1016/j.jare.2024.06.018 | en_US |
dc.identifier.issn | 2090-1232 | en_US |
dc.identifier.uri | https://hdl.handle.net/10356/180509 | - |
dc.description.abstract | Introduction: Adipogenesis, the process of white adipose tissue expansion, plays a critical role in the development of obesity. Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potential regulator in mediating adipogenesis during obesity onset. Objectives: This study aims to elucidate the involvement of OPG in adipogenesis during the early phases of diet-induced obesity and explore its therapeutic potential in obesity management. Methods: Using a diet-induced obesity model, we investigated OPG expression patterns in adipocytes and explored the mechanisms underlying its involvement in adipogenesis. We also assessed the effects of targeted silencing of OPG and recombinant OPG administration on obesity progression and insulin resistance. Additionally, the impact of electroacupuncture treatment on OPG levels and obesity management was evaluated in both animal models and human participants. Results: OPG expression was prominently activated in adipocytes of white adipose tissues during the early phase of diet-induced obesity. Hyperlipidemia induced Cbfa1-dependent OPG transcription, initiating and promoting adipogenesis, leading to cell-size expansion and lipid storage. Intracellular OPG physically bound to RAR and released the PPARɤ/RXR complex, activating adipogenesis-associated gene expression. Targeted silencing of OPG suppressed obesity development, while recombinant OPG administration promoted disease progression and insulin resistance in obese mice. Electroacupuncture treatment suppressed obesity development in an OPG-dependent manner and improved obesity parameters in obese human participants. Conclusion: OPG emerges as a key regulator in mediating adipogenesis during obesity development. Targeting OPG holds promise for the prevention and treatment of obesity, as evidenced by the efficacy of electroacupuncture treatment in modulating OPG levels and managing obesity-related outcomes. | en_US |
dc.description.sponsorship | Nanyang Technological University | en_US |
dc.language.iso | en | en_US |
dc.relation | 22387-00001 | en_US |
dc.relation.ispartof | Journal of Advanced Research | en_US |
dc.rights | © 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.subject | Medicine, Health and Life Sciences | en_US |
dc.title | Osteoprotegerin mediates adipogenesis in obesity | en_US |
dc.type | Journal Article | en |
dc.contributor.school | School of Biological Sciences | en_US |
dc.identifier.doi | 10.1016/j.jare.2024.06.018 | - |
dc.description.version | Published version | en_US |
dc.identifier.pmid | 38906326 | - |
dc.identifier.scopus | 2-s2.0-85196944993 | - |
dc.identifier.volume | 62 | en_US |
dc.identifier.spage | 245 | en_US |
dc.identifier.epage | 255 | en_US |
dc.subject.keywords | Osteoprotegerin | en_US |
dc.subject.keywords | Obesity | en_US |
dc.description.acknowledgement | This work is financially supported by the University Research Committee of The University of Hong Kong (Project Code: 104006600), Nanyang Technological University Research Committee (Project Code: #22387-00001), Research Grant Committee of Hong Kong (Project Code: 17119621), The Health and Medical Research Fund (Project Code: 19201591 and 15162961) and Innovation and Technology Fund (Project Code: PRP/028/22FX), Health and Medical Research Fund (Project Code: 15163331). | en_US |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | SBS Journal Articles |
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1-s2.0-S2090123224002558-main.pdf | 3.75 MB | Adobe PDF | View/Open |
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