Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/181047
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dc.contributor.authorTae, Hyunhyuken_US
dc.contributor.authorPark, Soohyunen_US
dc.contributor.authorChoe, Younghwanen_US
dc.contributor.authorYang, Chungmoen_US
dc.contributor.authorCho, Nam-Joonen_US
dc.date.accessioned2024-11-12T05:58:19Z-
dc.date.available2024-11-12T05:58:19Z-
dc.date.issued2024-
dc.identifier.citationTae, H., Park, S., Choe, Y., Yang, C. & Cho, N. (2024). Exploring the interfacial dynamics of unilamellar and multilamellar cationic liposomes on SiO2 and their interactions with membrane-active peptide. Langmuir. https://dx.doi.org/10.1021/acs.langmuir.4c02273en_US
dc.identifier.issn0743-7463en_US
dc.identifier.urihttps://hdl.handle.net/10356/181047-
dc.description.abstractUnderstanding the interplay between lipid assemblies and solid supports is crucial for advancing model membrane systems and biomedical applications. This study investigates the interfacial behaviors of unilamellar and multilamellar cationic liposomes on silicon dioxide and their interactions with a membrane-active AH peptide. Using QCM-D monitoring, unilamellar liposomes were found to rapidly form SLBs through one-step adsorption kinetics, whereas multilamellar liposomes exhibited slower adsorption. Further addition of liposomes caused fusogenic interactions with SLBs, where multilamellar liposomes formed more rigid lipid membranes. Upon AH peptide exposure, unilamellar-based lipid membranes showed higher susceptibility to structural transformations, achieving complete SLB formation, while multilamellar-based lipid membranes displayed reduced sensitivity and retained residual viscoelastic components, indicative of incomplete SLB formation. These findings underscore the significant influence of liposome lamellarity on their interfacial dynamics and peptide interactions, crucial for designing effective lipid-based delivery and sensing systems.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.language.isoenen_US
dc.relationRG111/20en_US
dc.relationRG34/22en_US
dc.relationREQ414940en_US
dc.relation.ispartofLangmuiren_US
dc.rights© 2024 American Chemical Society. All rights reserved.en_US
dc.subjectEngineeringen_US
dc.titleExploring the interfacial dynamics of unilamellar and multilamellar cationic liposomes on SiO2 and their interactions with membrane-active peptideen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doi10.1021/acs.langmuir.4c02273-
dc.identifier.pmid39267337-
dc.identifier.scopus2-s2.0-85203825913-
dc.subject.keywordsMembrane-active peptideen_US
dc.subject.keywordsCationic liposomesen_US
dc.description.acknowledgementThis research was supported by the Ministry of Education (MOE) in Singapore under Grants RG111/20 and RG34/22. In addition, this work was supported by the National Research Foundation in Singapore (NRF) under Grant REQ414940. H.T. is supported by a SINGA graduate scholarship from the A*STAR Graduate Academy, Singapore.en_US
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